Modern drug discovery and development heavily rely on the precise synthesis of peptides, and the choice of reagents is often the determining factor in success. Boc-Asp(OtBu)-OSu (CAS: 50715-50-9) is a prime example of a meticulously designed building block that significantly advances peptide synthesis. As a manufacturer specializing in high-quality peptide synthesis reagents, we provide these essential chemicals to researchers worldwide, enabling breakthroughs in pharmaceutical and biotechnological applications.

The chemical structure of Boc-Asp(OtBu)-OSu, officially N-alpha-tert-butoxycarbonyl-L-aspartic acid beta-tert-butyl ester alpha-N-hydroxysuccinimide ester, is engineered for optimal performance. It features three key functionalities that enable controlled peptide chain elongation. The N-alpha-Boc group serves as a standard, removable protecting group for the amino terminus, essential for preventing premature reactions. The beta-tert-butyl ester provides orthogonal protection to the side-chain carboxyl group of aspartic acid. This means it can be selectively removed without affecting other protecting groups, allowing for greater flexibility in complex peptide designs. The alpha-carboxyl group is activated as an N-hydroxysuccinimide (OSu) ester. This high-energy intermediate readily reacts with the free amine group of an incoming amino acid or peptide fragment, forming a stable peptide bond with high efficiency. This activation is why many researchers choose to buy Boc-Asp(OtBu)-OSu for their demanding synthesis needs.

The primary application of Boc-Asp(OtBu)-OSu lies in its role as a coupling reagent in both solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. In SPPS, it is attached to a resin-bound peptide chain, facilitating the sequential addition of amino acids. Its reactivity profile ensures that coupling reactions proceed smoothly, leading to higher overall yields and minimizing the formation of deletion or truncated sequences, which are common challenges in peptide synthesis. For those looking to buy this crucial reagent, understanding its properties and sourcing from a reliable manufacturer is key to ensuring the integrity of their peptide products.

The economic aspect is also significant; the Boc-Asp(OtBu)-OSu price can vary based on purity, volume, and supplier. However, the performance benefits often outweigh the cost, especially when dealing with high-value peptide therapeutics. By partnering with manufacturers who adhere to strict quality standards, researchers can confidently buy Boc-Asp(OtBu)-OSu, knowing they are using a reagent that contributes to the precision and success of their peptide synthesis workflows. We pride ourselves on being a dependable source for these critical chemical components, offering expert support alongside our product range.