Citalopram, a cornerstone in the treatment of depression and anxiety, is a complex molecule whose synthesis requires precise chemical steps involving specialized intermediates. Central to this process is 3-Oxo Citalopram, a compound identified by CAS number 372941-54-3, which serves as a vital precursor in its pharmaceutical production.

The chemical structure of 3-Oxo Citalopram (C20H19FN2O2) is designed to facilitate the final transformations needed to yield Citalopram. Its molecular weight is approximately 338.38 g/mol. Typically appearing as a pale yellow gel or solid, this intermediate exhibits hygroscopic properties, meaning it readily absorbs moisture from the air. Consequently, manufacturers must store it in dry conditions, ideally under refrigeration at 2-8°C and protected by an inert atmosphere to preserve its chemical integrity and prevent degradation.

The synthesis of Citalopram involves multiple stages, and the precise incorporation of the structural elements present in 3-Oxo Citalopram is key. This intermediate contains the essential fluorophenyl and isobenzofuran rings, along with the nitrile group and the dimethylaminopropyl side chain, albeit in a modified form that allows for subsequent reactions. The successful synthesis relies on the purity of 3-Oxo Citalopram, making reliable sourcing from manufacturers experienced in producing high-quality pharmaceutical intermediates crucial.

Researchers often seek out specific long tail keywords such as “Citalopram synthesis intermediate” or “buy 3-Oxo Citalopram online” to find suppliers who can provide this compound. The physical properties, such as its solubility in organic solvents, are also important considerations for chemists planning reaction sequences. Whether used in small research quantities or large-scale manufacturing, the consistent quality of 3-Oxo Citalopram directly impacts the yield and purity of the final Citalopram Active Pharmaceutical Ingredient (API).

Understanding the chemical journey from 3-Oxo Citalopram to Citalopram provides valuable insight into the complexities of pharmaceutical chemistry. It highlights the importance of sourcing high-quality intermediates from trusted global suppliers to ensure the efficacy and safety of essential medications. The careful management of its chemical properties and synthesis integration is fundamental to the success of Citalopram production.