In the realm of fine chemicals and pharmaceutical intermediates, molecules with intricate structures often hold the key to developing life-changing therapeutics. One such compound is 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile ethanedioate, identified by its CAS number 885340-12-5. This complex organic molecule is of significant interest to R&D scientists and procurement managers in the pharmaceutical industry.

The chemical structure of CAS 885340-12-5 reveals several key features that contribute to its importance:

  • Indoline Core: A heterocyclic aromatic organic compound forming the central scaffold. The presence of a cyano group at the 7-position is a notable feature.
  • Chiral Center: The molecule possesses a stereogenic center at the (2R)-2-aminopropyl substituent. Chirality is critical in pharmaceuticals, as different enantiomers can have vastly different biological activities and safety profiles.
  • Trifluoroethoxy Phenoxy Side Chain: This elaborate side chain, containing a trifluoroethoxy group, influences the molecule's lipophilicity, electronic properties, and metabolic stability. The trifluoroethoxy moiety, in particular, can enhance stability against enzymatic degradation.
  • Propyl Benzoate Ester: This functional group adds to the molecule's complexity and plays a role in its reactivity during subsequent synthesis steps.
  • Ethanedioate (Oxalate) Salt: The compound is typically supplied as an oxalate salt. Salt formation is a common strategy in pharmaceutical chemistry to improve a compound's physical properties, such as crystallinity, solubility, and handling characteristics, which are crucial for bulk purchasing and manufacturing.

The synthesis of such a complex molecule requires sophisticated chemical expertise. Manufacturers that can reliably produce CAS 885340-12-5 with high purity (typically ≥99%) and confirmed stereochemistry are invaluable partners for pharmaceutical R&D and manufacturing. For companies looking to buy this intermediate, understanding these structural elements helps in appreciating its value and the stringent quality required from its supplier.

The primary application of this compound is as a key intermediate in the synthesis of silodosin. The precise arrangement of its functional groups and its stereochemistry are critical for the effective conversion into the final active pharmaceutical ingredient. Therefore, when procuring this chemical, it is vital to partner with a manufacturer that prioritizes not just chemical synthesis, but also rigorous quality assurance and detailed product characterization.