For chemists, formulators, and procurement specialists in the pharmaceutical sector, understanding the intricate details of chemical intermediates is fundamental to successful drug development. Fosfluconazole, bearing the CAS number 194798-83-9, is a molecule of significant interest due to its role as a precursor in the synthesis of potent antifungal agents. This deep dive explores its chemical characteristics and importance.

Unpacking the Molecular Structure of Fosfluconazole

Fosfluconazole, chemically known as 1H-1,2,4-Triazole-1-ethanol, a-(2,4-difluorophenyl)-a-(1H-1,2,4-triazol-1-ylmethyl)-,1-(dihydrogen phosphate), is characterized by its complex yet highly functional molecular architecture. The formula C13H13F2N6O4P and a molecular weight of 386.2507 define its composition. Key features include:

  • Difluorophenyl Group: The presence of two fluorine atoms on the phenyl ring often enhances metabolic stability and lipophilicity, crucial for drug efficacy.
  • Triazole Rings: The 1,2,4-triazole moieties are common in antifungal drugs, as they interact with fungal cytochrome P450 enzymes, inhibiting ergosterol synthesis.
  • Ethanol and Phosphate Linkage: The ethanol backbone and the dihydrogen phosphate group provide a reactive site for further chemical modifications, essential for its role as an intermediate.

These structural elements collectively contribute to its utility in creating molecules with targeted biological activity.

Fosfluconazole in Pharmaceutical Synthesis

As a solid with 99% purity, Fosfluconazole serves as a critical intermediate for synthesizing triazole-class antifungal drugs. Its precise chemical structure allows for efficient conversion into active pharmaceutical ingredients (APIs) that combat a wide spectrum of fungal infections. For companies looking to buy Fosfluconazole, ensuring the supplier provides accurate structural information and purity data is paramount. Manufacturers in China, such as ourselves, specialize in producing these complex molecules efficiently and cost-effectively.

Procurement and Quality Assurance

When sourcing Fosfluconazole (CAS 194798-83-9), the emphasis must be on quality and reliability. A reputable manufacturer will provide detailed specifications, including appearance (solid), purity (99%), molecular weight, and density (1.7 g/cm³), along with a Certificate of Analysis. These details are vital for quality control and regulatory compliance in pharmaceutical manufacturing. For B2B buyers, identifying a trustworthy supplier that can consistently deliver high-quality Fosfluconazole at competitive prices is a strategic advantage.

Understanding the chemistry behind intermediates like Fosfluconazole empowers pharmaceutical professionals to make informed decisions. As a manufacturer committed to excellence, we offer this key intermediate with the assurance of quality and consistency. Contact us to discuss your requirements for Fosfluconazole and how we can support your drug development initiatives.