Methyl 2-bromoisonicotinate (CAS 26156-48-9) is a molecule of significant interest within the chemical community, primarily due to its utility as a versatile building block in complex organic synthesis. Understanding its chemical structure, synthesis pathways, and diverse applications provides valuable insight for researchers and manufacturers seeking to leverage its potential. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity material for your critical projects.

The molecular structure of Methyl 2-bromoisonicotinate features a pyridine ring, a six-membered heterocyclic aromatic ring containing one nitrogen atom. At the 2-position of this ring, a bromine atom is attached, serving as an excellent leaving group for various nucleophilic substitution and cross-coupling reactions. At the 4-position, a methyl ester group (-COOCH3) is present, which can undergo ester hydrolysis, transesterification, or reduction, further expanding its synthetic utility. Its empirical formula is C7H6BrNO2, and it has a molecular weight of approximately 216.032 g/mol. Physically, it typically presents as an off-white crystalline powder.

The synthesis of Methyl 2-bromoisonicotinate often involves the esterification of 2-bromoisonicotinic acid with methanol in the presence of an acid catalyst, such as concentrated sulfuric acid. This reaction is typically carried out under controlled heating conditions. Following the reaction, the product is isolated through solvent extraction and purification processes to achieve the desired high purity, often exceeding 98.0% assay. This precise synthesis is crucial for its role as a reliable intermediate for downstream applications.

The applications of Methyl 2-bromoisonicotinate are broad and impactful. In the pharmaceutical industry, it serves as a key intermediate for the synthesis of various APIs. Its pyridine core is a common motif in many biologically active molecules, and the bromine atom provides a facile handle for introducing complex side chains through modern cross-coupling methodologies. This makes it indispensable for medicinal chemists designing new drug candidates. Pharmaceutical companies looking to purchase this intermediate can rely on consistent quality from established suppliers.

Furthermore, in the realm of fine chemicals, Methyl 2-bromoisonicotinate is employed in the development of specialty chemicals, agrochemicals, and advanced materials. Its reactivity allows for the creation of novel heterocyclic compounds with tailored properties. Researchers often seek this compound for exploratory synthesis, aiming to discover new functional molecules. For those in the industry, understanding the availability and price of such intermediates is key to efficient project planning. As a dedicated manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides competitive pricing and ensures a stable supply chain for global customers aiming to buy this essential building block.

The journey from raw materials to advanced chemical products often hinges on the availability of high-quality intermediates like Methyl 2-bromoisonicotinate. Whether for pharmaceutical development or cutting-edge chemical research, securing this compound from a reputable source is paramount. Engaging with a trusted manufacturer who can offer both quality and volume is the strategic choice for any organization that depends on this versatile chemical.