Dexlansoprazole, with its CAS number 138530-94-6, is a compound of significant interest in medicinal chemistry due to its therapeutic applications as a proton pump inhibitor (PPI). As a fine chemical manufacturer specializing in pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. understands the critical importance of its chemical properties and how they translate into effective patient outcomes.

Chemically, Dexlansoprazole is the R-enantiomer of lansoprazole. Its molecular formula is C16H14F3N3O2S, and it possesses a molecular weight of approximately 369.36 g/mol. The molecule features a benzimidazole ring system linked via a sulfinyl group to a substituted pyridine ring. The pyridine ring is functionalized with a methyl group and a 2,2,2-trifluoroethoxy group, which contributes to its unique pharmacological profile. This specific chiral configuration is crucial for its enhanced therapeutic activity compared to the racemic mixture of lansoprazole.

As a PPI, Dexlansoprazole works by irreversibly inhibiting the H+/K+-ATPase enzyme system, commonly known as the proton pump, located in the gastric parietal cells. This inhibition effectively reduces gastric acid secretion, providing symptomatic relief and promoting healing in conditions like GERD. The structure is designed to be absorbed in the small intestine and then activated in the acidic environment of the parietal cells, where it covalently binds to the proton pump.

NINGBO INNO PHARMCHEM CO.,LTD. ensures that the synthesis of Dexlansoprazole yields a product of high purity (≥99%), which is vital for its intended pharmaceutical use. Our expertise in complex organic synthesis allows us to control the stereochemistry and minimize unwanted byproducts, guaranteeing a consistent and reliable API intermediate. Understanding the chemical intricacies of Dexlansoprazole allows us to provide our clients with a product that meets the highest standards of quality and efficacy.

The development and manufacturing of pharmaceutical intermediates like Dexlansoprazole require a deep understanding of chemistry and a commitment to quality. NINGBO INNO PHARMCHEM CO.,LTD. prides itself on its scientific expertise and advanced manufacturing capabilities, positioning itself as a key partner for companies seeking high-quality chemical building blocks for their pharmaceutical innovations.