Delving into the chemistry of Sarcosine Methyl Ester Hydrochloride (CAS 13515-93-0) reveals its importance as a foundational compound for various scientific and industrial applications. As a derivative of sarcosine, this molecule offers unique chemical properties that make it indispensable in fields ranging from peptide synthesis to pharmaceutical research. Understanding its synthesis and characteristics is key for anyone looking to utilize it effectively.

Sarcosine Methyl Ester Hydrochloride, a white to beige crystalline powder, is defined by its chemical formula C4H10ClNO2 and a molecular weight of approximately 139.58 g/mol. Its structure features a methyl ester group attached to the carboxyl of sarcosine, and it exists as a hydrochloride salt. This salt form enhances its water solubility and stability, making it easier to handle and incorporate into various chemical reactions. The compound is also noted for being hygroscopic, meaning it readily absorbs moisture from the air, requiring storage in tightly sealed containers.

The synthesis of Sarcosine Methyl Ester Hydrochloride typically involves the esterification of sarcosine. Common methods include reacting sarcosine with methanol in the presence of an acid catalyst, such as sulfuric acid or thionyl chloride. Alternatively, the trimethylchlorosilane-methanol system is a widely favored method for its efficiency and milder reaction conditions, often yielding the desired product in good to excellent yields. The process of forming the hydrochloride salt usually involves treating the methyl ester with hydrochloric acid. These synthetic routes are well-established and allow for laboratory-scale preparation as well as industrial production.

Key chemical properties that make Sarcosine Methyl Ester Hydrochloride valuable include:

  • Water Solubility: Its hydrochloride salt form ensures good solubility in water, facilitating its use in aqueous reaction systems.
  • Reactivity: The ester group and the secondary amine provide sites for further chemical modification, making it an excellent building block for more complex molecules.
  • Stability: As a hydrochloride salt, it exhibits greater stability compared to its free base form, improving shelf life and handling.

In research settings, particularly for peptide synthesis, Sarcosine Methyl Ester Hydrochloride acts as a crucial N-methylated amino acid precursor. Its incorporation can influence the conformation and biological activity of synthetic peptides. In pharmaceutical research, it serves as an intermediate for creating novel drug candidates, particularly those targeting neurological pathways. The demand for this compound is robust, driven by its fundamental role in organic synthesis and its application in developing advanced materials and therapeutics.

For entities looking to buy Sarcosine Methyl Ester Hydrochloride, partnering with a reliable manufacturer or supplier is essential. Sourcing from established manufacturers, often located in China, can provide access to high-purity material at competitive prices. It's imperative for purchasers to verify product specifications and seek out suppliers who offer comprehensive technical data and consistent quality, ensuring the compound meets the stringent requirements for advanced chemical synthesis.

In summary, the synthesis and chemical properties of Sarcosine Methyl Ester Hydrochloride (CAS 13515-93-0) underscore its significance in modern chemistry. Its versatility as a building block for peptides and pharmaceuticals, coupled with its favorable chemical characteristics, makes it a sought-after compound for research and industrial applications. Reliable sourcing from quality-conscious manufacturers is key to unlocking its full potential.