Sodium Carboxymethyl Starch (CMS), often referred to as Sodium Starch Glycolate (SSG), is a chemically modified derivative of starch that has found indispensable applications in the pharmaceutical industry, primarily as a superdisintegrant. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing pharmaceutical-grade CMS, and understanding its chemical nature is key to appreciating its efficacy.

Chemically, Sodium Carboxymethyl Starch is synthesized by treating starch with sodium chloroacetate under alkaline conditions. This carboxymethylation process introduces carboxymethyl groups (-CH2COONa) onto the starch polymer chains. The degree of substitution (DS), which refers to the average number of carboxymethyl groups per glucose unit, significantly influences the properties of the final product. A higher DS generally leads to increased water solubility and swelling capacity, which are critical for its function as a disintegrant.

The hygroscopic nature of CMS means it readily attracts and absorbs moisture from its surroundings. Upon contact with water, the carboxymethyl groups become ionized, increasing the hydrophilicity of the molecule. This leads to rapid hydration and significant swelling of the starch particles. This physical transformation is the primary mechanism by which it acts as an effective pharmaceutical disintegrant. The swelling creates internal pressure within the tablet matrix, causing it to disintegrate quickly into smaller particles, thereby facilitating drug dissolution. The ability to buy Sodium Starch Glycolate in bulk from reliable sources like NINGBO INNO PHARMCHEM CO.,LTD. ensures consistent chemical properties for formulation.

Our Sodium Carboxymethyl Starch is manufactured to meet international standards, complying with USP, BP, EP, and CP. This rigorous quality control ensures that the chemical structure and properties are precisely managed, providing formulators with a predictable and reliable hygroscopic pharmaceutical excipient powder. The fast expanding starch for tablets that we provide is a testament to our commitment to chemical excellence.

As an effective pharmaceutical disintegrant, Sodium Starch Glycolate offers a unique combination of properties. Its ability to enhance tablet hardness while promoting rapid disintegration makes it a versatile choice for many oral solid dosage forms. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to pharmaceutical advancements by supplying this essential, chemically optimized excipient.