For those involved in chemical synthesis, understanding the production methods and fundamental chemistry of key intermediates is crucial. 1-Phenyl-5-mercaptotetrazole (CAS 86-93-1), a compound with significant utility in the photographic and pharmaceutical sectors, is no exception. This article explores its synthesis and key chemical characteristics, providing valuable insights for chemists, R&D professionals, and procurement specialists.

Chemical Identity and Properties

1-Phenyl-5-mercaptotetrazole (C7H6N4S) is characterized by its tetrazole ring structure, which contains four nitrogen atoms, and a mercapto (-SH) group attached to the fifth position of the ring, with a phenyl group substituted on one of the nitrogen atoms. Typically appearing as a white to off-white crystalline powder or solid, it exhibits moderate solubility in organic solvents like ethanol and chloroform, and limited solubility in water.

Its key physicochemical properties include:

  • Molecular Weight: 178.21 g/mol
  • Melting Point: Approximately 145°C (with decomposition)
  • Flash Point: Around 138°C
  • CAS Number: 86-93-1

These properties influence its handling, storage, and application in various chemical processes.

Synthesis Routes for 1-Phenyl-5-mercaptotetrazole

The synthesis of 1-Phenyl-5-mercaptotetrazole typically involves cyclization reactions using readily available precursors. One common method described in literature involves the reaction of phenyl isothiocyanate with sodium azide. The process generally includes the following steps:

  1. Reaction of Phenyl Isothiocyanate and Sodium Azide: Phenyl isothiocyanate is reacted with sodium azide, often in a polar solvent like water or dimethyl sulfoxide (DMSO), under controlled temperature and reflux conditions. This step leads to the formation of a sodium salt intermediate.
  2. Acidification: The resulting sodium salt is then acidified, typically with hydrochloric acid, to a specific pH. This protonates the intermediate, causing 1-Phenyl-5-mercaptotetrazole to precipitate out of the solution as a white solid.
  3. Purification: The crude product is then filtered, washed with water to remove residual salts, and dried. Further purification, often through recrystallization from a suitable solvent like dilute ethanol, yields the high-purity compound required for industrial applications.

Yields for this synthesis are generally reported to be high, often exceeding 90% after purification, making it an economically viable route for manufacturers.

Importance for Manufacturers and Buyers

For chemical manufacturers, understanding and optimizing these synthesis routes ensures efficient production and cost-effectiveness. For buyers, knowledge of these methods helps in assessing supplier capabilities and product quality. When sourcing 1-Phenyl-5-mercaptotetrazole, inquiring about the manufacturing process and quality control measures can provide confidence in the product's suitability for your specific needs. If you are looking to buy this intermediate, partnering with a manufacturer that specializes in producing it with consistent purity is essential.

Conclusion

The chemistry behind 1-Phenyl-5-mercaptotetrazole (CAS 86-93-1) and its synthesis pathways highlight its importance as a chemical building block. By understanding these aspects, professionals can better evaluate suppliers and ensure they are obtaining a high-quality product. For businesses requiring this compound, partnering with a knowledgeable chemical manufacturer that prioritizes quality and efficient synthesis is key to successful procurement and application.