The efficacy of modern pharmaceuticals often hinges on the precise chemical structure and purity of their constituent intermediates. Vilazodone Hydrochloride (CAS 163521-12-8) stands out as a critical molecule in the pharmaceutical industry, particularly in the development of novel antidepressants. Understanding its chemical synthesis and pharmacological mechanism is essential for both researchers and manufacturers.

Chemically, Vilazodone is an indolylbutylpiperazine derivative. Its synthesis typically involves the coupling of precursor molecules, such as an indolylbutyl chloride or tosylate, with a piperazine moiety, for instance, 5-(piperazin-1-yl)benzofuran-2-carboxamide or its corresponding ester. The specific arrangement of the cyanoindole group and the benzofuran carboxamide portion is crucial for its interaction with biological targets. As a leading manufacturer, we ensure that our production processes yield Vilazodone HCl with the highest possible purity, minimizing byproducts and ensuring consistent quality for downstream pharmaceutical applications.

Pharmacologically, Vilazodone operates through a dual mechanism: it is a potent and selective inhibitor of the serotonin transporter (SERT), and a high-affinity partial agonist of the 5-HT1A receptor. This dual action is key to its therapeutic effect in treating Major Depressive Disorder (MDD). By inhibiting SERT, Vilazodone increases the concentration of serotonin in the synaptic cleft. Simultaneously, its partial agonism at 5-HT1A receptors, particularly on presynaptic autoreceptors, can lead to a more rapid desensitization of these feedback mechanisms, potentially resulting in a faster onset of antidepressant action compared to traditional SSRIs alone.

This sophisticated mechanism of action makes Vilazodone HCl a highly sought-after intermediate. For pharmaceutical companies looking to buy Vilazodone HCl, partnering with a reliable manufacturer that understands these complex chemical and pharmacological requirements is vital. Our facility is equipped to handle the precise synthesis steps needed to produce pharmaceutical-grade Vilazodone HCl, meeting the stringent demands of the industry. We offer this critical intermediate, ensuring that researchers and manufacturers have access to a reliable supply for developing next-generation CNS therapeutics.

The ability to source high-purity Vilazodone HCl from a trusted manufacturer in China provides a significant advantage. It allows for consistent R&D efforts and scaled-up production. We are committed to supporting the pharmaceutical industry by providing this essential building block. If your work involves CNS drug discovery or the synthesis of sophisticated APIs, exploring our offerings for Vilazodone HCl is a crucial step. Request a quote today to secure your supply from an expert manufacturer dedicated to chemical excellence.