Understanding Fmoc-Dab(Z)-OH: A Chemist's Guide to Peptide Synthesis
For chemists engaged in peptide synthesis, a deep understanding of the building blocks employed is fundamental to success. Fmoc-Dab(Z)-OH, a derivative of L-2,4-diaminobutyric acid, is a prime example of a specialized amino acid that offers unique advantages in constructing complex peptide sequences through solid-phase peptide synthesis (SPPS). This guide aims to provide clarity on its chemical characteristics and essential applications.
Fmoc-Dab(Z)-OH, identified by CAS 252049-08-4, is characterized by two distinct protecting groups: the Fmoc group on the alpha-amino function and the Z (benzyloxycarbonyl) group on the side-chain amino group. The Fmoc moiety is widely favored in SPPS due to its lability under mild basic conditions (e.g., piperidine treatment), allowing for its facile removal without damaging the growing peptide chain or sensitive side-chain modifications. This is crucial for maintaining the integrity of the peptide during iterative coupling cycles.
The Z-protection on the epsilon-amino group of the diaminobutyric acid side chain provides orthogonal protection. This means it can be removed selectively, often under acidic conditions (e.g., TFA cleavage from the resin) or via hydrogenolysis, without affecting the Fmoc group or other acid-labile protecting groups commonly used in SPPS. This orthogonal protection strategy is a key reason why chemists choose Fmoc-Dab(Z)-OH when they need to introduce specific functionalities or create branched peptide structures. Researchers often look for 'Fmoc-Dab(Z)-OH applications' to understand its potential in their synthesis designs.
When sourcing this vital reagent, chemists and lab managers will search for 'buy Fmoc-Dab(Z)-OH online' or 'Fmoc-L-2,4-diaminobutyric acid Z-OH supplier'. The quality of the material is paramount, with high purity levels (often 99%+) being essential for reproducible synthesis outcomes. Factors such as enantiomeric purity, absence of residual solvents, and well-defined batch-to-batch consistency are critical considerations. Choosing a reputable manufacturer ensures that the product meets the stringent demands of peptide synthesis.
The incorporation of Fmoc-Dab(Z)-OH can lead to peptides with enhanced biological activity, improved pharmacokinetic profiles, or the ability to be conjugated to other molecules. Its presence can be beneficial in areas such as peptide drug development, diagnostics, and the creation of novel biomaterials. The availability of this building block at a competitive price from reliable manufacturers, particularly those in China, allows research teams to explore a wider range of peptide designs.
In essence, Fmoc-Dab(Z)-OH is more than just another amino acid derivative; it is a sophisticated tool for peptide chemists. Understanding its protective group chemistry and application potential is key to unlocking new possibilities in peptide design and synthesis. For those looking to source this indispensable compound, NINGBO INNO PHARMCHEM CO.,LTD. stands as a dedicated manufacturer and supplier committed to quality and supporting scientific advancement.
Fmoc-Dab(Z)-OH, identified by CAS 252049-08-4, is characterized by two distinct protecting groups: the Fmoc group on the alpha-amino function and the Z (benzyloxycarbonyl) group on the side-chain amino group. The Fmoc moiety is widely favored in SPPS due to its lability under mild basic conditions (e.g., piperidine treatment), allowing for its facile removal without damaging the growing peptide chain or sensitive side-chain modifications. This is crucial for maintaining the integrity of the peptide during iterative coupling cycles.
The Z-protection on the epsilon-amino group of the diaminobutyric acid side chain provides orthogonal protection. This means it can be removed selectively, often under acidic conditions (e.g., TFA cleavage from the resin) or via hydrogenolysis, without affecting the Fmoc group or other acid-labile protecting groups commonly used in SPPS. This orthogonal protection strategy is a key reason why chemists choose Fmoc-Dab(Z)-OH when they need to introduce specific functionalities or create branched peptide structures. Researchers often look for 'Fmoc-Dab(Z)-OH applications' to understand its potential in their synthesis designs.
When sourcing this vital reagent, chemists and lab managers will search for 'buy Fmoc-Dab(Z)-OH online' or 'Fmoc-L-2,4-diaminobutyric acid Z-OH supplier'. The quality of the material is paramount, with high purity levels (often 99%+) being essential for reproducible synthesis outcomes. Factors such as enantiomeric purity, absence of residual solvents, and well-defined batch-to-batch consistency are critical considerations. Choosing a reputable manufacturer ensures that the product meets the stringent demands of peptide synthesis.
The incorporation of Fmoc-Dab(Z)-OH can lead to peptides with enhanced biological activity, improved pharmacokinetic profiles, or the ability to be conjugated to other molecules. Its presence can be beneficial in areas such as peptide drug development, diagnostics, and the creation of novel biomaterials. The availability of this building block at a competitive price from reliable manufacturers, particularly those in China, allows research teams to explore a wider range of peptide designs.
In essence, Fmoc-Dab(Z)-OH is more than just another amino acid derivative; it is a sophisticated tool for peptide chemists. Understanding its protective group chemistry and application potential is key to unlocking new possibilities in peptide design and synthesis. For those looking to source this indispensable compound, NINGBO INNO PHARMCHEM CO.,LTD. stands as a dedicated manufacturer and supplier committed to quality and supporting scientific advancement.
Perspectives & Insights
Agile Reader One
“Fmoc-Dab(Z)-OH, identified by CAS 252049-08-4, is characterized by two distinct protecting groups: the Fmoc group on the alpha-amino function and the Z (benzyloxycarbonyl) group on the side-chain amino group.”
Logic Vision Labs
“The Fmoc moiety is widely favored in SPPS due to its lability under mild basic conditions (e.”
Molecule Origin 88
“, piperidine treatment), allowing for its facile removal without damaging the growing peptide chain or sensitive side-chain modifications.”