Chloroquine Diphosphate is a compound that has garnered significant attention in both clinical practice and scientific research due to its diverse pharmacological activities. Understanding its properties, synthesis, and applications is crucial for researchers and pharmaceutical professionals alike. This article provides an overview of Chloroquine Diphosphate, from its chemical makeup to its utility in drug discovery.

Chemical Profile and Synthesis

Chloroquine Diphosphate, with the CAS number 50-63-5, is the diphosphate salt of chloroquine. Its molecular formula is C18H26ClN3·2H3PO4, and it has a molecular weight of approximately 515.86 g/mol. It typically appears as a white crystalline powder, soluble in water. The synthesis of chloroquine and its salts involves multi-step chemical processes, often starting with precursors like 4,7-dichloroquinoline and N,N-diethyl-1,4-pentanediamine derivatives. Manufacturers focus on optimizing these synthetic routes to achieve high purity and yield, ensuring the final product meets stringent quality standards.

Pharmacological Properties and Applications

Chloroquine Diphosphate exhibits a range of pharmacological actions, leading to its application in various fields:

  • Antimalarial Activity: Its most well-known application is as an antimalarial agent. It interferes with the malaria parasite's ability to digest hemoglobin and detoxify heme, leading to its death. While resistance is a concern for certain malaria strains, it remains a key therapeutic for specific types of infection and prophylaxis.
  • Anti-inflammatory and Immunomodulatory Effects: Chloroquine Diphosphate is also employed in treating autoimmune diseases, such as rheumatoid arthritis and lupus erythematosus. It acts by modulating immune responses and reducing inflammatory processes.
  • Antiviral and Anticancer Research: In recent years, Chloroquine Diphosphate has been investigated for its potential in antiviral therapies (including early research into COVID-19) and as an adjuvant in cancer treatment. Its ability to inhibit autophagy, a cellular process that cancer cells can exploit for survival, makes it a subject of interest in oncology research.
  • Cellular Biology Research: As a tool compound, it is used to study autophagy, apoptosis, and lysosomal function in various cell models.

Sourcing High-Quality Chloroquine Diphosphate

For researchers and pharmaceutical developers, sourcing high-purity Chloroquine Diphosphate is critical for obtaining reliable experimental results and formulating effective medications. When looking to buy Chloroquine Diphosphate, it is essential to partner with reputable manufacturers and suppliers who can guarantee:

  • Exceptional Purity: Aim for products with a stated purity of 99% or higher, verified by analytical testing.
  • Consistent Quality: Ensure batch-to-batch consistency, supported by detailed CoAs.
  • Regulatory Compliance: Manufacturers adhering to GMP and ISO standards are preferred for pharmaceutical applications.
  • Technical Support: Access to technical data and support enhances the usability of the product.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality Chloroquine Diphosphate, catering to the needs of researchers and the pharmaceutical industry. We ensure stringent quality control and reliable supply to support your critical projects and formulations.