The field of gene therapy and nucleic acid delivery has seen remarkable advancements, largely driven by the development of effective delivery vehicles. Among the most crucial components of these systems are cationic lipids, and DOTMA Chloride Salt stands out as a premier choice for researchers worldwide. As a leading manufacturer and supplier in China, we understand the importance of high-quality reagents in achieving successful experimental outcomes.

DOTMA, chemically known as (cis/trans)-1,2-di-octadecenyl-3-trimethylammonium propane (chlorides salt) with CAS number 104872-42-6, is a synthetic cationic lipid that has been foundational in lipofection techniques. Its unique structure allows it to interact with negatively charged DNA or RNA, forming complexes that are capable of fusing with cell membranes. This fusion process is key to delivering genetic material directly into the cell's cytoplasm, enabling gene expression or other therapeutic interventions.

Why is DOTMA Chloride Salt a Preferred Choice?

The effectiveness of DOTMA Chloride Salt stems from several key characteristics:

  • High Transfection Efficiency: Compared to older methods like calcium phosphate precipitation or DEAE-dextran, lipofection using DOTMA has consistently demonstrated superior efficiency, often by several orders of magnitude. This makes it an attractive option for those looking to buy DOTMA Chloride Salt for research where high yields are critical.
  • Liposome Formulation: DOTMA is a vital component in the creation of liposomes and lipid nanoparticles (LNPs). These nanocarriers are essential for protecting nucleic acids from degradation and facilitating their targeted delivery. When formulating, ensuring a consistent and pure cationic lipid is paramount, making reliable DOTMA lipid suppliers like us indispensable.
  • Versatility in Applications: From academic research labs to pharmaceutical companies, DOTMA is employed in a wide range of applications, including the delivery of plasmids, siRNA, and mRNA. Its ability to stabilize complexes and promote cellular uptake makes it invaluable for developing gene-based therapeutics and vaccines.
  • Structural Advantages: Research has shown that the specific structure of DOTMA, including the ether linkages and the oleyl chains, contributes significantly to its high in vivo transfection activity. This understanding guides formulators in selecting the most effective cationic lipids for their specific needs.

Procuring High-Quality DOTMA Chloride Salt

For researchers and developers, sourcing high-purity reagents is non-negotiable. As a dedicated DOTMA lipid supplier in China, we pride ourselves on offering products that meet stringent quality control standards. Our commitment extends to providing competitive DOTMA price for research, ensuring that your budget is not a barrier to groundbreaking scientific exploration. When you need to purchase DOTMA Chloride Salt for your next project, consider the benefits of working with a trusted manufacturer.

Whether you are working on novel gene therapies, developing RNA-based vaccines, or optimizing lipid nanoparticle formulations, high-quality DOTMA Chloride Salt is a critical ingredient. We are here to support your endeavors by providing reliable access to this essential biochemical. Contact us today to inquire about our product specifications, availability, and to request a quote for your research needs.