Carbodiimides are a vital class of reagents widely utilized across organic synthesis, peptide chemistry, and material sciences. Among them, N,N'-Di-tert-butylcarbodiimide (CAS 691-24-7) stands out for its specific advantages, particularly its stability and the nature of its by-products. For procurement managers and research scientists, understanding these distinctions is key to selecting the optimal reagent for their applications.

Understanding Carbodiimide Chemistry and Its Applications

Carbodiimides, with the general formula R-N=C=N-R', function primarily as dehydrating agents. They facilitate the formation of amide and ester bonds by activating carboxylic acids. The most common carbodiimides used in synthesis include Dicyclohexylcarbodiimide (DCC) and Diisopropylcarbodiimide (DIC), alongside N,N'-Di-tert-butylcarbodiimide (DTBC). Each has its own set of advantages and disadvantages concerning reactivity, solubility, and by-product management.

N,N'-Di-tert-butylcarbodiimide: Unique Advantages

N,N'-Di-tert-butylcarbodiimide offers several key benefits that differentiate it from other carbodiimides:

  • Stability: The bulky tert-butyl groups provide significant steric hindrance, leading to higher stability and reduced propensity for unwanted side reactions, particularly in sensitive syntheses.
  • By-product Solubility: Unlike DCC, which forms insoluble Dicyclohexylurea (DCU) that can be difficult to remove, the urea by-product from DTBC is generally more soluble in common organic solvents. This simplifies purification processes, saving time and resources in laboratory and industrial settings.
  • Reduced Racemization: In peptide synthesis, where maintaining stereochemical integrity is crucial, DTBC often exhibits a lower tendency to cause racemization of amino acid residues compared to some other coupling agents.

These attributes make N,N'-Di-tert-butylcarbodiimide a preferred choice for specific applications, especially when purity and ease of purification are critical.

Sourcing N,N'-Di-tert-butylcarbodiimide from China

For professionals looking to buy N,N'-Di-tert-butylcarbodiimide, identifying a reliable N,N'-Di-tert-butylcarbodiimide manufacturer in China is an excellent strategy. Chinese suppliers often provide high-purity N,N'-Di-tert-butylcarbodiimide (typically ≥98.5%) at competitive CAS 691-24-7 price points. When you purchase N,N'-Di-tert-butylcarbodiimide, working with an experienced N,N'-Di-tert-butylcarbodiimide supplier ensures you receive consistent quality and dependable supply, essential for scaling up your chemical processes. This strategic sourcing can significantly benefit your procurement budget and operational efficiency.

Choosing the right carbodiimide is a technical decision that impacts reaction success. N,N'-Di-tert-butylcarbodiimide offers distinct advantages that can streamline your synthesis and purification protocols. Contact us to learn more about our high-quality N,N'-Di-tert-butylcarbodiimide offerings and to secure your supply.