The Impact of Cilengitide Trifluoroacetate on Cancer Cell Adhesion and Invasion
Cancer cell adhesion and invasion are fundamental processes that contribute to tumor metastasis, a primary cause of cancer-related mortality. These processes are heavily mediated by cell surface receptors, particularly integrins, which facilitate interactions between cancer cells and the surrounding extracellular matrix (ECM). Understanding and targeting these interactions is key to developing effective anti-cancer strategies. Cilengitide Trifluoroacetate plays a significant role in this area of research.
Cilengitide Trifluoroacetate is a potent inhibitor of integrins αvβ3 and αvβ5, which are known to be critical for cancer cell adhesion and invasion. These integrins bind to ECM proteins such as vitronectin, fibronectin, and laminin, which provide scaffolding and signaling cues that promote cancer cell migration and infiltration into surrounding tissues and blood vessels. By blocking the activity of these integrins, Cilengitide disrupts these essential interactions.
In preclinical studies, Cilengitide has been shown to significantly inhibit the adhesion of various cancer cells, including melanoma and glioma cells, to vitronectin. This reduced adhesion correlates with a decreased ability of these cells to invade through barriers like Matrigel, which mimics the ECM. This anti-invasive property is a direct consequence of disrupting integrin-mediated signaling pathways that control cytoskeletal organization and cell motility.
The impact of Cilengitide Trifluoroacetate extends to its role in drug development, where it serves as a vital research tool for scientists investigating the molecular mechanisms of cancer metastasis. Its consistent availability from reliable suppliers, such as ourselves, ensures that researchers can conduct rigorous studies to further elucidate these mechanisms and develop novel therapeutic interventions. Purchasing Cilengitide Trifluoroacetate supports critical research aimed at overcoming cancer cell adhesion and invasion, a crucial step in combating the disease. We are committed to providing the global research community with high-quality pharmaceutical intermediates to fuel these vital investigations.
Cilengitide Trifluoroacetate is a potent inhibitor of integrins αvβ3 and αvβ5, which are known to be critical for cancer cell adhesion and invasion. These integrins bind to ECM proteins such as vitronectin, fibronectin, and laminin, which provide scaffolding and signaling cues that promote cancer cell migration and infiltration into surrounding tissues and blood vessels. By blocking the activity of these integrins, Cilengitide disrupts these essential interactions.
In preclinical studies, Cilengitide has been shown to significantly inhibit the adhesion of various cancer cells, including melanoma and glioma cells, to vitronectin. This reduced adhesion correlates with a decreased ability of these cells to invade through barriers like Matrigel, which mimics the ECM. This anti-invasive property is a direct consequence of disrupting integrin-mediated signaling pathways that control cytoskeletal organization and cell motility.
The impact of Cilengitide Trifluoroacetate extends to its role in drug development, where it serves as a vital research tool for scientists investigating the molecular mechanisms of cancer metastasis. Its consistent availability from reliable suppliers, such as ourselves, ensures that researchers can conduct rigorous studies to further elucidate these mechanisms and develop novel therapeutic interventions. Purchasing Cilengitide Trifluoroacetate supports critical research aimed at overcoming cancer cell adhesion and invasion, a crucial step in combating the disease. We are committed to providing the global research community with high-quality pharmaceutical intermediates to fuel these vital investigations.
Perspectives & Insights
Nano Explorer 01
“The impact of Cilengitide Trifluoroacetate extends to its role in drug development, where it serves as a vital research tool for scientists investigating the molecular mechanisms of cancer metastasis.”
Data Catalyst One
“Its consistent availability from reliable suppliers, such as ourselves, ensures that researchers can conduct rigorous studies to further elucidate these mechanisms and develop novel therapeutic interventions.”
Chem Thinker Labs
“Purchasing Cilengitide Trifluoroacetate supports critical research aimed at overcoming cancer cell adhesion and invasion, a crucial step in combating the disease.”