NINGBO INNO PHARMCHEM CO.,LTD. stays at the forefront of pharmaceutical developments, and 6-O-Benzylguanine (CAS 19916-73-5) is a compound with a notable history and evolving research interest. Understanding where and how to buy 6-O-Benzylguanine is essential for researchers exploring its therapeutic potential.

Historically, 6-O-Benzylguanine was investigated for its potential as an antineoplastic agent, particularly in combination therapies for certain cancers. Its mechanism of action as a suicide inhibitor of O6-alkylguanine-DNA alkyltransferase (AGT) was theorized to enhance the efficacy of DNA-damaging chemotherapy agents, such as alkylating drugs. The goal was to deplete the cellular capacity for DNA repair, thereby increasing the lethality of chemotherapy for cancer cells.

While early clinical trials showed promise, the combination of 6-O-Benzylguanine with certain agents, like temozolomide for glioblastoma, encountered challenges related to toxicity without a definitive increase in clinical benefit. This led to a more nuanced understanding of its application and the importance of precise dosing and combination strategies. Despite these findings, the scientific community continues to explore the potential of this O6-Benzylguanine DNA repair inhibitor.

Current research trends are focused on refining the understanding of its pharmacokinetic and pharmacodynamic properties, as well as exploring its use in different cancer types or in novel drug delivery systems. Researchers aiming to purchase 6-O-Benzylguanine are often looking to investigate its role in modulating gene expression related to DNA repair, or its potential in combination with newer targeted therapies. The compound's function as a guanine derivative antineoplastic agent remains a key area of investigation.

In conclusion, 6-O-Benzylguanine represents a fascinating case study in pharmaceutical research. Its journey from initial clinical exploration to its current role as a vital research tool underscores the dynamic nature of drug development. NINGBO INNO PHARMCHEM CO.,LTD. supports these ongoing investigations by providing high-quality 6-O-Benzylguanine for research purposes.