In the dynamic field of pharmaceutical research and development, the availability of high-quality chemical intermediates is crucial for innovation. Clodronate Disodium Salt (CAS 22560-50-5) stands out as a versatile compound with significant applications, particularly in areas concerning bone metabolism and immune system modulation. For R&D scientists and procurement specialists, understanding its applications and how to source it effectively is key to advancing scientific discovery and product development.

Understanding the Core Properties of Clodronate Disodium Salt

Clodronate Disodium Salt is a synthetic bisphosphonate, a class of drugs known for their ability to inhibit osteoclast activity and reduce bone resorption. Typically supplied as a white crystal powder with high water solubility, its chemical structure, containing two chlorine atoms attached to a methylene diphosphonate core, is central to its biological activity. Purity, often exceeding 98%, is a critical specification for researchers and formulators to ensure predictable results.

Key Applications in Pharmaceutical R&D:

  • Bone Health Research: Clodronate Disodium Salt is widely utilized in research to understand and target conditions characterized by excessive bone breakdown, such as osteoporosis and bone metastases. Its ability to bind to hydroxyapatite crystals and interfere with osteoclast function makes it an invaluable tool for studying bone remodeling processes. Researchers often buy Clodronate Disodium Salt to investigate new therapeutic strategies for these conditions.
  • Immunomodulation Studies: Beyond bone health, Clodronate Disodium Salt has demonstrated immunomodulatory effects, particularly its capacity to deplete macrophages. This property is leveraged in studies investigating inflammatory diseases, autoimmune disorders, and the role of macrophages in various physiological and pathological processes. Scientists looking to manipulate immune cell populations will seek reliable suppliers for this compound.
  • Cancer Research: The compound's impact on bone and its effects on immune cells have also made it relevant in cancer research, especially concerning skeletal metastases and the tumor microenvironment. Its use in developing novel cancer therapies or as a research tool to understand tumor progression is a growing area.
  • Preclinical Drug Development: As a chemical intermediate, Clodronate Disodium Salt serves as a building block or a reference compound in the preclinical development of new bisphosphonate drugs or related therapies. Ensuring a consistent and high-quality supply from a manufacturer is paramount for these long-term research projects.

Sourcing Strategies for R&D Professionals

When procuring Clodronate Disodium Salt for R&D, prioritize suppliers who can guarantee high purity and offer robust technical support. Manufacturers in China are often a primary source due to their production capabilities and competitive pricing. When requesting a quote, clearly state your purity requirements and the intended research application. Understanding the supplier's production capacity and their adherence to quality control standards will ensure you receive a product that meets your stringent R&D needs.

Conclusion: Enabling Innovation with Quality Intermediates

Clodronate Disodium Salt (CAS 22560-50-5) is a compound of significant interest in pharmaceutical R&D, offering diverse applications in bone health, immunology, and oncology. By partnering with experienced manufacturers and suppliers from China, researchers can access this vital chemical intermediate with the assurance of high purity and stable supply. We are committed to supporting your innovative research endeavors. Contact us to learn more about our Clodronate Disodium Salt offerings.