The development and widespread availability of effective anticoagulant medications are critical in managing cardiovascular health and preventing thrombotic events. Among these vital drugs is Rivaroxaban, a direct oral anticoagulant that has significantly impacted patient care. The synthesis of Rivaroxaban relies heavily on high-quality pharmaceutical intermediates, and one such crucial component is the Rivaroxaban Intermediate Hydrochloride (CAS 898543-06-1). Understanding the significance of this compound and ensuring its reliable sourcing is paramount for pharmaceutical manufacturers globally.

What is Rivaroxaban Intermediate Hydrochloride?

Rivaroxaban Intermediate Hydrochloride, a fine chemical with the CAS number 898543-06-1, serves as a key building block in the multi-step synthesis of Rivaroxaban. Its precise chemical structure, often described as a morpholinone derivative, is engineered to facilitate specific reactions that ultimately form the active pharmaceutical ingredient (API). The 'hydrochloride' designation indicates it's a salt form, often preferred for its improved solubility and handling properties compared to the free base, making it easier to incorporate into manufacturing processes. The requirement for high purity is non-negotiable, as any impurities could compromise the safety and efficacy of the final drug product.

Why is Purity Essential for Pharmaceutical Intermediates?

In the pharmaceutical industry, the adage 'garbage in, garbage out' holds particularly true for raw materials and intermediates. For a compound like Rivaroxaban Intermediate Hydrochloride, achieving a purity of u226599% is standard practice. This stringent purity ensures that downstream reactions proceed as expected, minimizing the formation of unwanted by-products that could be difficult and costly to remove. Furthermore, regulatory bodies worldwide impose strict limits on impurities in APIs. Sourcing from a reputable manufacturer that adheres to rigorous quality control standards is therefore essential for any company looking to buy this critical intermediate.

Sourcing Strategies: Finding a Reliable Supplier in China

China has emerged as a global hub for chemical manufacturing, offering a vast array of intermediates for the pharmaceutical sector. For procurement managers and R&D scientists seeking to purchase Rivaroxaban Intermediate Hydrochloride, identifying a reliable supplier in China is a strategic advantage. A trustworthy manufacturer will not only provide the required purity but also offer competitive pricing, consistent supply, and transparent communication regarding production and delivery. When evaluating potential suppliers, consider their manufacturing capabilities, quality certifications, and their track record in serving the pharmaceutical industry.

The Commercial Aspect: Price and Availability

The price of pharmaceutical intermediates can fluctuate based on raw material costs, production volumes, and market demand. However, a well-established manufacturer can offer competitive prices for bulk orders of Rivaroxaban Intermediate Hydrochloride. For businesses planning to buy this compound, obtaining a quote from several reputable suppliers is a wise approach. Factors like payment terms (L/C, T/T, D/P, etc.) and Incoterms (FOB, CFR, CIF, EXW) also play a role in the overall cost and logistical planning. Working with a supplier that offers flexible options in these areas can significantly streamline the procurement process.

In conclusion, Rivaroxaban Intermediate Hydrochloride (CAS 898543-06-1) is an indispensable component in the production of Rivaroxaban. For pharmaceutical companies aiming to maintain high product standards and efficient manufacturing, partnering with a leading manufacturer and supplier in China that offers high-purity products, competitive pricing, and dependable service is key to success. When you need to buy this essential intermediate, prioritize quality, reliability, and a strong supplier relationship.