In the realm of organic chemistry, certain molecules stand out due to their unique structural attributes and versatile reactivity. Cyclopropyl Acetylene, identified by its CAS number 6746-94-7, is one such compound. Characterized by the fusion of a strained cyclopropane ring with an ethynyl group, this chemical serves as a highly valuable intermediate for a wide range of synthetic applications, particularly within the pharmaceutical and fine chemical sectors. Understanding its properties and how to source it efficiently is crucial for scientists and procurement managers.

Chemical Profile and Properties

Cyclopropyl Acetylene, also known as Ethynylcyclopropane, presents itself typically as a clear, colorless to pale yellow liquid or powder depending on the source and purity. Its molecular formula is C5H6, with a molecular weight of approximately 66.10 g/mol. The presence of the cyclopropane ring imparts significant ring strain, which influences its reactivity and makes it prone to specific types of chemical transformations. The terminal alkyne functionality is highly reactive, participating readily in reactions such as cycloadditions, additions, and coupling reactions.

Key physical and chemical properties often cited include:

  • Boiling Point: Around 78-82°C (lit.).
  • Flash Point: Typically below -15°C, indicating its flammable nature.
  • Solubility: Miscible with common organic solvents like THF and DCM, with limited solubility in water.
  • Purity: High purity grades, often exceeding 98.5% by GC, are readily available from specialized manufacturers, which is essential for critical synthesis steps.

Applications Driving Demand for Cyclopropyl Acetylene

The unique structure and reactivity of Cyclopropyl Acetylene translate into diverse and critical applications:

  • Pharmaceutical Intermediates: This is arguably the most significant application. Cyclopropyl Acetylene is a key building block in the synthesis of numerous Active Pharmaceutical Ingredients (APIs). It is often employed in the development pathways for antiviral medications, kinase inhibitors, and other complex therapeutic agents where the cyclopropyl motif is integral to biological activity. When you buy Cyclopropyl Acetylene for pharmaceutical R&D or manufacturing, you are acquiring a molecule proven to enable the creation of potent drugs.
  • Click Chemistry: Its terminal alkyne functionality makes it an excellent participant in azide-alkyne cycloaddition (AAC) reactions, particularly copper-free variants. This makes it invaluable for bioconjugation, drug discovery, and creating functionalized materials. Researchers frequently need to purchase this for its precision in forming stable triazole linkages.
  • Material Science: Cyclopropyl Acetylene can be used as a monomer or crosslinking agent in the synthesis of specialized polymers. Its incorporation can lead to materials with enhanced thermal stability, rigidity, or specific electronic properties.
  • Agrochemicals: The cyclopropane ring is a known pharmacophore in some pesticides and herbicides. Cyclopropyl Acetylene can therefore serve as a starting material for developing new crop protection agents.

Sourcing Cyclopropyl Acetylene

For those looking to purchase Cyclopropyl Acetylene, partnering with established manufacturers is crucial. Reputable suppliers, such as NINGBO INNO PHARMCHEM CO.,LTD., provide high-purity grades, competitive pricing, and reliable supply chains. We offer detailed product specifications and support for your procurement needs, whether for laboratory research or industrial-scale production. Contact us to learn more about how you can buy this essential intermediate.