D(+)10-Camphorsulfonic Acid: A Key Chiral Intermediate in Pharmaceutical Manufacturing
In the highly regulated and precision-driven pharmaceutical industry, the selection and reliable sourcing of chemical intermediates are critical to the successful development and manufacturing of life-saving drugs. D(+)10-Camphorsulfonic Acid, identified by its CAS number 3144-16-9, is a prime example of such an essential chiral intermediate. Its unique chemical structure and properties make it indispensable in the synthesis of several important pharmaceuticals, most notably the widely used antiplatelet drug, Clopidogrel.
D(+)10-Camphorsulfonic Acid is a chiral organic compound derived from camphor. Its optical activity, specifically its dextrorotatory nature, is what makes it particularly valuable in pharmaceutical synthesis. Many drug molecules are chiral, meaning they exist as non-superimposable mirror images (enantiomers). Often, only one enantiomer exhibits the desired therapeutic effect, while the other may be inactive or even detrimental. D(+)10-Camphorsulfonic Acid is employed as a chiral resolving agent, meaning it can be used to separate these enantiomers from a racemic mixture, thereby isolating the therapeutically active form.
The primary industrial application that drives significant demand for D(+)10-Camphorsulfonic Acid is its use as a key intermediate in the synthesis of Clopidogrel. Clopidogrel is a vital medication prescribed to reduce the risk of heart attack and stroke in individuals with a history of cardiovascular disease. The successful synthesis of Clopidogrel sulfate and Clopidogrel camphorsulfonate relies on the availability of high-purity D(+)10-Camphorsulfonic Acid. Manufacturers in this sector must ensure a consistent and reliable supply from qualified suppliers to maintain production continuity and product quality.
As a strong organic acid, D(+)10-Camphorsulfonic Acid also finds utility as a catalyst in various organic synthesis reactions. Its catalytic properties are leveraged in processes such as esterification and etherification, where it can significantly improve reaction efficiency and product yields. This makes it a valuable reagent for chemical manufacturers involved in the production of fine chemicals and complex organic molecules beyond just pharmaceuticals.
For businesses aiming to procure D(+)10-Camphorsulfonic Acid, understanding the critical success factors is vital. These include ensuring the material meets stringent purity standards (typically ≥99%), as well as securing a consistent supply from a reputable manufacturer. Given China's significant role in global chemical manufacturing, identifying a trustworthy supplier in this region can provide access to high-quality intermediates at competitive prices. Working with such suppliers, who often provide detailed product specifications and Certificates of Analysis, ensures that procurement aligns with the rigorous demands of the pharmaceutical industry.
In essence, D(+)10-Camphorsulfonic Acid is a cornerstone chemical for specific pharmaceutical manufacturing pathways. Its role in producing essential medications highlights the importance of diligent sourcing and quality assurance. By partnering with reliable manufacturers and suppliers, companies can ensure they have access to this crucial chiral intermediate, thereby supporting the production of vital healthcare products worldwide.
Perspectives & Insights
Quantum Pioneer 24
“In the highly regulated and precision-driven pharmaceutical industry, the selection and reliable sourcing of chemical intermediates are critical to the successful development and manufacturing of life-saving drugs.”
Bio Explorer X
“D(+)10-Camphorsulfonic Acid, identified by its CAS number 3144-16-9, is a prime example of such an essential chiral intermediate.”
Nano Catalyst AI
“Its unique chemical structure and properties make it indispensable in the synthesis of several important pharmaceuticals, most notably the widely used antiplatelet drug, Clopidogrel.”