D-2-Thienylalanine, a chiral amino acid derivative identified by CAS number 62561-76-6, is a compound of significant interest across multiple scientific and industrial sectors. Its unique structure, combining an amino acid backbone with a thiophene ring, lends itself to a variety of applications, from pharmaceutical synthesis to advanced materials. This article provides an overview of its synthesis, key applications, and how to effectively source this specialized chemical globally, with a focus on reputable manufacturers and suppliers.

Synthesis of D-2-Thienylalanine

The synthesis of D-2-Thienylalanine typically involves stereoselective methods to ensure the correct D-configuration at the alpha-carbon. Common approaches might include chiral pool synthesis, asymmetric catalysis, or enzymatic resolution. For instance, starting materials like 2-thiophenecarboxaldehyde can be utilized in Strecker synthesis variations or other amination protocols, followed by chiral resolution or asymmetric induction to obtain the desired enantiomer. Manufacturers focus on optimizing these synthetic routes to achieve high yields and purities, often exceeding 98% or 99% via HPLC. The efficiency and cost-effectiveness of the synthesis directly impact the market price and availability of D-2-Thienylalanine.

Key Applications of D-2-Thienylalanine

The versatility of D-2-Thienylalanine is reflected in its diverse applications:

  • Pharmaceuticals: It serves as a crucial building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system or acting as peptide mimetics. Its structure can enhance drug stability, binding affinity, or bioavailability.
  • Biochemical Research: Researchers use it in studies involving protein structure-activity relationships, enzyme kinetics, and as a component in the design of diagnostic probes.
  • Material Science: The thiophene ring makes it a candidate for developing functionalized polymers for organic electronics, sensors, or conductive materials.
  • Flavors and Fragrances: While less common, its aromatic and heterocyclic nature suggests potential applications in creating novel flavor profiles or fragrance components.

These varied uses underscore the importance of accessing high-quality D-2-Thienylalanine with reliable specifications.

Global Supply and Procurement Strategies

Finding a dependable source for D-2-Thienylalanine (CAS 62561-76-6) is critical for any research or manufacturing endeavor. Key global suppliers and manufacturers are located in regions with strong chemical production infrastructure, including China, Europe, and North America. When you need to buy D-2-Thienylalanine, it is advisable to:

  • Verify Purity and Documentation: Always request a Certificate of Analysis (CoA) confirming purity and specifications.
  • Compare Suppliers: Obtain quotes from multiple manufacturers to ensure competitive pricing and favorable terms.
  • Consider Bulk Orders: Purchasing larger quantities typically reduces the per-unit cost significantly.
  • Evaluate Reliability: Choose suppliers with a proven track record, strong quality control, and responsive customer service.

Manufacturers in China, in particular, offer competitive pricing and a wide range of specialized chemicals. By working directly with a manufacturer, you can often streamline the procurement process and ensure a stable supply chain.

In summary, D-2-Thienylalanine (CAS 62561-76-6) is a valuable and versatile compound. Understanding its synthesis, applications, and how to efficiently source it from reputable global manufacturers is key to supporting innovation in pharmaceuticals, research, and materials development.