Amoxicillin, a cornerstone antibiotic in global healthcare, relies heavily on the quality and availability of its key precursors. Among these, D(-)-4-Hydroxyphenylglycine (CAS 22818-40-2) plays an indispensable role. This high-purity intermediate is not just a chemical compound; it is a critical component that dictates the efficiency and success of Amoxicillin manufacturing. For procurement specialists and R&D scientists in the pharmaceutical industry, understanding the nuances of sourcing this vital raw material is crucial for maintaining competitive edge and ensuring product integrity.

The Chemical Foundation of Amoxicillin

D(-)-4-Hydroxyphenylglycine, a chiral alpha-amino acid, provides the specific side chain required for the potent antibacterial activity of Amoxicillin. Its structure, featuring a hydroxyphenyl group and a D-configured amino acid core, is meticulously integrated into the penicillin nucleus during synthesis. The purity of D(-)-4-Hydroxyphenylglycine directly influences the final Amoxicillin product's efficacy and safety profile. Impurities present in the intermediate can lead to side reactions, reduced yields, and potentially problematic byproducts in the API, underscoring the importance of selecting a reputable manufacturer.

What to Look for When Buying D(-)-4-Hydroxyphenylglycine

When a pharmaceutical company decides to buy D(-)-4-Hydroxyphenylglycine, the primary considerations should revolve around quality assurance and supply chain reliability. Prospective buyers should seek suppliers who can provide detailed specifications, including a minimum assay of 99.00%, alongside specific rotation data, moisture content, and heavy metal limits. A supplier's ability to consistently deliver material that meets these stringent standards is paramount. Inquiries about D(-)-4-Hydroxyphenylglycine price should always be coupled with an assessment of the overall value proposition, including the supplier's adherence to Good Manufacturing Practices (GMP) where applicable, and their regulatory support capabilities.

Choosing a Trusted Manufacturer and Supplier

The global market offers numerous D(-)-4-Hydroxyphenylglycine suppliers, but identifying a manufacturer with robust production capabilities and a strong commitment to quality is essential. Companies looking for a stable supply of this intermediate often turn to specialized chemical manufacturers. For those seeking to purchase D(-)-4-Hydroxyphenylglycine, a partner that offers competitive pricing from China, coupled with excellent customer service and timely delivery, can significantly benefit their operations. It is advisable to engage with suppliers who can provide samples for testing and validation prior to placing bulk orders.

In conclusion, D(-)-4-Hydroxyphenylglycine is more than just a raw material; it's a critical element in the synthesis of a globally important antibiotic. By carefully selecting a qualified D(-)-4-Hydroxyphenylglycine manufacturer and supplier, pharmaceutical companies can ensure the consistent production of high-quality Amoxicillin, contributing to effective patient treatment and market success.