Biomedical research is an intricate discipline that relies heavily on precise tools and reagents to unravel biological processes and develop new therapies. Among these essential reagents, specific amino acid derivatives often play unexpected yet critical roles. D-Valine (CAS 640-68-6), a non-proteinogenic isomer of valine, has gained recognition for its unique application as a selective agent in cell culture. This property makes it an invaluable asset for researchers working with cell lines, particularly when isolating specific cell populations or studying cellular behaviors. For any research institution or laboratory manager, understanding the specific benefits of D-Valine and how to reliably source it is paramount.

The key to D-Valine's utility in cell culture lies in its interaction with the enzyme D-amino acid oxidase (DAO). Many cell types, especially primary cultures or those derived from specific tissues, may contain a mixture of cells. For instance, epithelial cells might be cultured alongside contaminating fibroblasts. Fibroblasts, a type of connective tissue cell, often lack significant levels of DAO. In contrast, epithelial cells typically possess functional DAO. When D-Valine is added to the culture medium, cells lacking DAO (like fibroblasts) are inhibited or killed because they cannot metabolize D-Valine. Cells that possess DAO (like epithelial cells) can utilize or tolerate D-Valine, allowing for their selective growth and proliferation. This selective inhibition is a powerful technique for enriching cultures with the desired cell type.

This selective property of D-Valine has been demonstrated in various research contexts. It has been used to inhibit the proliferation of contaminating fibroblasts in cultures of smooth muscle cells from human myometrium, ensuring that the smooth muscle cells, which are the primary focus of the study, can be isolated and maintained effectively. Furthermore, D-Valine has been investigated for its role in tumor growth inhibition in experimental models, showing improvements in the nutritional status of hepatoma-bearing rats. While these are preclinical findings, they underscore the distinct biological activities that D-Valine exhibits, differentiating it from its L-enantiomer.

For researchers, the ability to purchase high-purity D-Valine is crucial for reproducible and reliable experimental results. Impurities could interfere with the selective mechanisms or introduce unintended cellular responses. Sourcing D-Valine from reputable manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., guarantees access to a product that meets the high standards required for sensitive biological experiments. Our commitment to quality ensures that the D-Valine you buy is precisely what you need for successful cell culture and research applications. We understand the importance of consistent material for scientific breakthroughs.

The availability of D-Valine at competitive prices also makes advanced cell culture techniques more accessible. Many research laboratories operate with strict budgets, and cost-effective sourcing of essential reagents like D-Valine can significantly impact the feasibility of long-term studies. By providing D-Valine at attractive prices, we aim to support the broader scientific community in their pursuit of knowledge and therapeutic discovery.

In conclusion, D-Valine (CAS 640-68-6) is a vital reagent in biomedical research, primarily due to its function as a selective agent in cell culture. Its ability to inhibit cells lacking D-amino acid oxidase allows researchers to isolate and cultivate specific cell types more efficiently. For scientists and procurement managers, partnering with a reliable supplier in China ensures access to high-purity D-Valine, supporting the integrity and success of their research. We are dedicated to supplying the scientific community with the quality reagents needed to advance our understanding of biology and medicine.