In the realm of pharmaceutical chemistry, specific molecules stand out for their efficacy and versatility. Flutrimazole, identified by the CAS number 119006-77-8, is one such compound that has carved a significant niche as a topical antifungal agent. This article delves into the multifaceted aspects of Flutrimazole, covering its physical and chemical characteristics, its therapeutic applications in managing skin infections, and its broader significance as a pharmaceutical intermediate.

Chemically, Flutrimazole is an imidazole derivative characterized by the molecular formula C22H16F2N2 and a molecular weight of approximately 346.37 g/mol. It typically presents as a white to pale yellow solid, often in a powder form. Its solubility profile indicates practical insolubility in water but good solubility in organic solvents like tetrahydrofuran and methanol. These properties are crucial for its formulation into topical preparations, ensuring effective delivery to the site of infection. The presence of fluorine atoms in its structure contributes to its enhanced lipophilicity and interaction with fungal enzymes.

The primary application of Flutrimazole lies in its potent antifungal activity, particularly against superficial mycoses of the skin. It is highly effective against dermatophytes, filamentous fungi, and yeasts, which are common culprits behind various dermatological conditions. The flutrimazole mechanism of action involves the inhibition of a key fungal enzyme, lanosterol 14α-demethylase. This enzyme is essential for the biosynthesis of ergosterol, a vital component of the fungal cell membrane. By disrupting ergosterol synthesis, Flutrimazole compromises the structural integrity of the fungal cell, leading to its death. This precise targeting makes it an effective agent for antifungal skin infections.

Beyond its antifungal properties, Flutrimazole also possesses anti-inflammatory characteristics, which can be advantageous in soothing irritated skin and reducing the symptoms associated with fungal infections. The excellent local and systemic tolerance observed in patients further solidifies its utility in dermatological treatments. When considering the procurement of such specialized chemical compounds, understanding the nuances of their properties and applications is paramount. NINGBO INNO PHARMCHEM CO., LTD. is dedicated to supplying high-quality chemical products that meet the rigorous standards of the pharmaceutical industry. We recognize the importance of compounds like Flutrimazole in the development of effective treatments and strive to be a reliable partner in the pharmaceutical supply chain. Exploring the benefits of Flutrimazole CAS 119006-77-8 is essential for researchers and manufacturers in the field.