The pharmaceutical industry constantly seeks advanced molecules to address unmet medical needs. Deucravacitinib, a novel drug for treating certain immune-mediated diseases, represents a significant advancement. At the heart of its synthesis lies a series of precise chemical transformations, often relying on specialized intermediates. One such crucial compound is 4,6-Dichloro-3-pyridazinecarboxylic Acid (CAS: 1040246-87-4).

What is Deucravacitinib and its Synthesis Pathway?

Deucravacitinib is a first-in-class, selective tyrosine kinase 2 (TYK2) inhibitor. Its development targets inflammatory pathways involved in conditions like plaque psoriasis. The synthesis of such complex molecules typically involves multiple steps, where specific chemical intermediates are essential for building the core structure and introducing functional groups.

4,6-Dichloro-3-pyridazinecarboxylic Acid: A Key Intermediate

4,6-Dichloro-3-pyridazinecarboxylic Acid, a halogenated pyridazine derivative, plays a pivotal role in the multi-step synthesis of Deucravacitinib. Its molecular structure, C5H2Cl2N2O2, provides the necessary framework and reactive sites for subsequent chemical modifications required to form the Deucravacitinib molecule. As an off-white powder, its purity is critical to ensure efficient reaction progression and to minimize the formation of unwanted byproducts during the complex synthesis process.

Researchers and manufacturers aiming to produce Deucravacitinib must source high-quality 4,6-Dichloro-3-pyridazinecarboxylic Acid. When you look to buy this intermediate, ensuring it meets the stringent purity requirements (often 98% or higher) is paramount. The reliability of the supplier, especially manufacturers in China, is key to maintaining a consistent supply for ongoing production or research phases.

Sourcing Strategies for Researchers

For R&D scientists and procurement managers, identifying reliable suppliers for critical intermediates like 4,6-Dichloro-3-pyridazinecarboxylic Acid is a strategic imperative. When searching for 'Deucravacitinib intermediate supplier' or 'buy 4,6-dichloropyridazine-3-carboxylic acid CAS 1040246-87-4,' it's essential to:

  • Verify Manufacturer Credentials: Look for companies with established quality control systems and a history of supplying pharmaceutical intermediates.
  • Request Certificates of Analysis (CoA): Ensure the CoA details purity, identification, and any significant impurities.
  • Evaluate Pricing and Lead Times: Obtain quotes and compare them, considering bulk discounts and estimated delivery times to manage project timelines and budgets effectively.

The availability of high-quality 4,6-Dichloro-3-pyridazinecarboxylic Acid from reputable manufacturers directly impacts the efficiency and success of Deucravacitinib synthesis. By focusing on quality sourcing and reliable partnerships, the pharmaceutical industry can continue to bring innovative treatments to patients.