Peptide synthesis is a cornerstone of modern biotechnology, pharmaceutical research, and diagnostics. Central to this intricate process are high-quality amino acid building blocks. DL-Histidine (CAS 4998-57-6) stands out as a crucial component, particularly its imidazole side chain, which imparts unique functional properties to synthesized peptides. As a specialized DL-Histidine manufacturer China, we provide the high-purity amino acid derivatives essential for successful peptide synthesis, ensuring researchers can confidently buy DL-Histidine online.

The Significance of Histidine in Peptide Structures

Histidine, and by extension DL-Histidine, is characterized by its imidazole ring. This functional group is pivotal in several aspects of peptide chemistry and biology:

  • Catalytic Activity: The imidazole ring can act as a proton shuttle, making histidine residues vital in the active sites of many enzymes. Incorporating DL-Histidine into synthesized peptides can confer or enhance catalytic properties.
  • Metal Ion Coordination: The nitrogen atoms in the imidazole ring readily coordinate with metal ions, such as zinc, copper, and iron. This property is exploited in designing metallopeptides for various therapeutic or diagnostic applications.
  • pH Buffering: The pKa of the imidazole ring (around 6.0) allows histidine residues to buffer pH changes in the physiological range. This is important for maintaining peptide stability and function in biological environments.
  • Protein Folding and Interactions: Histidine residues often participate in hydrogen bonding and electrostatic interactions that contribute to the correct folding of proteins and their interactions with other biomolecules.

Choosing the Right DL-Histidine for Synthesis

For peptide synthesis, the quality and purity of the amino acid building blocks are non-negotiable. When you purchase DL-Histidine, it's essential to source from a reliable DL-Histidine supplier that guarantees high purity (typically >98% or >99%) and consistency. The specific form, H-DL-His-OH, is often used in solid-phase peptide synthesis (SPPS) or solution-phase methods. While L-Histidine is commonly used for biological activity, DL-Histidine can be employed when the racemic mixture is acceptable or in specific synthesis strategies.

A reputable DL-Histidine manufacturer China will provide:

  • Detailed Certificates of Analysis (CoA) confirming purity and key physicochemical properties.
  • Consistent batch-to-batch quality for reproducible synthesis results.
  • Adequate technical support regarding product specifications and handling.
  • Competitive pricing, especially for bulk orders, making us an ideal DL-Histidine wholesale supplier.

Securing Your Peptide Synthesis Reagents

The success of your peptide synthesis projects hinges on the quality of your starting materials. By partnering with a trusted chemical supplier, you can ensure a reliable supply of DL-Histidine. We are dedicated to supporting the scientific community by providing high-quality amino acid derivatives. If you are looking for a dependable DL-Histidine price quote or need to source H-DL-His-OH for your peptide synthesis, reach out to us today. Our commitment as a leading DL-Histidine supplier means you get the quality and service you need to advance your research.