For researchers and developers in the pharmaceutical and chemical industries, a thorough understanding of the chemical properties of intermediates is fundamental to successful synthesis and application. DL-Homocysteine Thiolactone Hydrochloride (CAS 6038-19-3) is a compound of significant interest, particularly due to its role as a precursor in drug manufacturing. This article delves into its key chemical characteristics, solubility, and its broader implications in research and development.

Chemical Identity and Structure

DL-Homocysteine Thiolactone Hydrochloride is a white crystalline powder with the molecular formula C4H8ClNOS and a molecular weight of 153.63 g/mol. Its structure features a thiolactone ring derived from homocysteine, along with a hydrochloride salt, which enhances its stability and solubility. The CAS number 6038-19-3 uniquely identifies this compound. Its IUPAC name, 3-aminothiolan-2-one;hydrochloride, provides a precise description of its chemical architecture.

Key Chemical Properties

Several properties make DL-Homocysteine Thiolactone Hydrochloride valuable:

  • Appearance: It is typically described as a White Crystalline Powder.
  • Melting Point: The reported melting point is around 202 °C, often with decomposition (dec.), indicating thermal sensitivity.
  • Solubility: A key advantage is its good solubility in water (740.5 g/L at 20 °C), as well as solubility in DMSO and methanol. This solubility profile facilitates its use in aqueous and polar organic reaction systems, common in pharmaceutical synthesis.
  • Stability: While generally stable under recommended storage conditions (cool, dry, well-ventilated place, away from light and oxidizing agents), its handling requires attention to prevent degradation.
  • Purity: For pharmaceutical applications, high purity (≥99.0%) is essential, as mandated by stringent industry standards.

Applications and Research Implications

The primary application of DL-Homocysteine Thiolactone Hydrochloride is as a crucial intermediate in the synthesis of pharmaceutical products, most notably Erdosteine, a widely used mucolytic agent. Its unique chemical structure and reactivity make it an excellent building block for creating complex organic molecules. Beyond direct synthesis, the compound is also of interest in biochemical research for:

  • Studying Homocysteine Metabolism: Its relation to homocysteine makes it valuable for research into metabolic disorders and related diseases.
  • Protein Modification Studies: Researchers investigate its role in protein N-homocysteinylation, a post-translational modification linked to cellular dysfunction.
  • Oxidative Stress Research: It can be used in experimental models to explore the mechanisms of oxidative stress.

Sourcing from NINGBO INNO PHARMCHEM CO.,LTD.

As a leading supplier, NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality DL-Homocysteine Thiolactone Hydrochloride to meet the demands of both industrial synthesis and research laboratories. We ensure our product adheres to strict specifications, offering a reliable source for this important chemical. If you are looking to buy DL-Homocysteine Thiolactone Hydrochloride or require detailed information on its properties and applications, we encourage you to contact us. Our commitment to quality and customer support makes us an ideal partner for your chemical sourcing needs.