In the complex world of pharmaceutical research and development, understanding drug metabolism is as crucial as discovering the parent drug itself. Metabolites, the substances produced when the body breaks down a drug, can offer profound insights into pharmacokinetics, efficacy, and potential side effects. One such important compound is 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone, identified by its CAS number 53786-28-0, which is a key metabolite of the widely used gastrokinetic and antinauseant drug, Domperidone.

The Significance of 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone

As a chemical intermediate, 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone plays a vital role in several areas of pharmaceutical research:

  1. Drug Metabolism Studies: Its primary significance lies in its identity as a human metabolite of Domperidone. Researchers studying the metabolism and pharmacokinetics of Domperidone utilize this compound to understand how the drug is processed, absorbed, and excreted by the body. This knowledge is critical for optimizing dosage regimens and predicting drug interactions.
  2. Impurity Profiling: In the manufacturing of Domperidone, understanding and controlling related impurities, including metabolites, is essential for regulatory compliance and drug safety. High-purity 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone serves as a reference standard in analytical testing to ensure the quality of the final Domperidone product.
  3. Drug Discovery and Development: While its direct therapeutic application is limited, its unique benzimidazolone structure, coupled with the piperidine moiety, makes it an interesting scaffold for further chemical modification. As a valuable chemical intermediate, it can be used in the synthesis of novel compounds with potential therapeutic activities, perhaps in related fields or for entirely new indications.
  4. Analytical Reference Standard: For laboratories involved in pharmaceutical analysis, having a reliable source for characterized compounds like 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone is indispensable. Its availability from reputable manufacturers ensures accurate identification and quantification in complex biological matrices.

Sourcing and Quality Assurance

The reliable sourcing of such specialized intermediates is a task handled by dedicated chemical manufacturers and suppliers. Companies that specialize in pharmaceutical intermediates, like ourselves, ensure that 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone is produced to stringent purity standards, often exceeding 95%, and with a well-defined melting point (228-231 °C). This meticulous attention to quality control is vital for its use as a reference standard or as a building block in further synthesis. We are committed to providing this essential compound with consistent quality and availability to researchers and pharmaceutical companies globally.

Understanding the role of drug metabolites like 5-Chloro-1-(4-piperidyl)-2-benzimidazolinone is fundamental to advancing pharmaceutical science. Its availability as a high-quality chemical intermediate empowers researchers to conduct more precise studies and accelerate the development of safer, more effective medications. We invite you to inquire about our offerings and explore how our reliable supply of this critical compound can support your research objectives.