In the realm of organic chemistry, the selection of high-quality starting materials and intermediates is fundamental to achieving successful and reproducible synthetic outcomes. 3-Chloro-2-methylbenzonitrile, identified by CAS number 54454-12-5, is a compound that consistently proves its value in various synthetic strategies. Its specific arrangement of a nitrile group, a chlorine atom, and a methyl group on a benzene ring provides unique reactivity that chemists can leverage for complex molecular construction. For those looking to optimize their organic synthesis processes, understanding the benefits and sourcing of this specific benzonitrile derivative is crucial.

The Chemical Profile of 3-Chloro-2-methylbenzonitrile

This compound is characterized by its molecular formula C8H6ClN and a molecular weight of approximately 151.59 g/mol. A key attribute for its application in meticulous organic synthesis is its high purity, typically offered at 99% or higher by reputable manufacturers. Physically, it presents as a light yellow to yellow solid, with a melting point range of 34-36°C, indicating a stable form under standard laboratory conditions. These parameters ensure that when you purchase 3-Chloro-2-methylbenzonitrile, you are obtaining a material that will behave predictably in your reactions.

Leveraging 3-Chloro-2-methylbenzonitrile in Synthesis

The versatility of 3-Chloro-2-methylbenzonitrile in organic synthesis stems from its dual functionality. The nitrile group can be converted into a variety of other functional groups, such as amines, amides, or carboxylic acids, through well-established chemical transformations. Simultaneously, the aryl chloride moiety can participate in cross-coupling reactions like Suzuki, Heck, or Sonogashira couplings, allowing for the introduction of diverse substituents onto the aromatic ring. This makes it an ideal starting material for building complex heterocyclic systems, advanced materials, and key intermediates for pharmaceuticals and agrochemicals. When looking to buy this compound, inquire about its suitability for specific reaction types.

Sourcing Strategies for Optimal Results

To ensure the integrity of your organic synthesis projects, it is imperative to source 3-Chloro-2-methylbenzonitrile from reliable manufacturers and suppliers. Companies specializing in fine chemicals and pharmaceutical intermediates, particularly those based in China, often provide these materials at competitive prices and with high purity. When evaluating potential suppliers, consider their production capacity, quality control measures, and delivery capabilities for worldwide distribution. Requesting a free sample is a standard practice to confirm the product's quality before placing a larger order. Understanding the nuances of purchasing such chemicals, including obtaining necessary documentation like a Certificate of Analysis (CoA), will streamline your procurement process.

Key Considerations for Purchasing

Beyond purity and price, factors such as packaging, storage recommendations, and the supplier's responsiveness are important. A well-established manufacturer will typically provide clear storage instructions (e.g., sealed in dry conditions at room temperature) to maintain product integrity. By partnering with a trusted supplier, you can ensure a consistent and reliable supply of 3-Chloro-2-methylbenzonitrile for all your organic synthesis needs.

In summary, 3-Chloro-2-methylbenzonitrile (CAS 54454-12-5) is a valuable asset for any organic chemist. By prioritizing purity and selecting a reputable manufacturer and supplier, you can enhance the efficiency and success rate of your synthetic endeavors.