Osteoarthritis (OA) is a debilitating condition characterized by joint pain and stiffness, and the search for effective treatments is ongoing. A significant area of research involves the development of selective cathepsin K inhibitors. At the heart of synthesizing these advanced therapeutic agents lies a key chemical intermediate: trans-1,2-cyclohexanedicarboxylic acid (CAS: 2305-32-0).

Trans-1,2-Cyclohexanedicarboxylic Acid: A Cornerstone for OA Therapies

This white crystalline powder (C8H12O4) is recognized for its utility as a reagent in the synthesis of specific (α-cyanoalkyl)(tetrahydropyrido[4,3-b]indolecarbonyl)cyclohexanecarboxamides and their analogs. These compounds are designed to selectively target cathepsin K, an enzyme implicated in cartilage degradation. For researchers and formulators in the pharmaceutical industry, the availability of a high-purity trans-1,2-cyclohexanedicarboxylic acid is essential for achieving the desired selectivity and efficacy in the final drug product.

Procurement Considerations for Research and Development

When your R&D team identifies trans-1,2-cyclohexanedicarboxylic acid as a critical component for your osteoarthritis treatment program, several procurement factors come into play:

  • Product Specifications: Ensure the supplier can provide detailed specifications, including purity (≥98.0%), physical appearance, and any relevant analytical data. This is crucial for scientists who need to buy materials that meet strict research standards.
  • Supplier Reputation: Partnering with a reputable manufacturer or a trusted chemical supplier ensures product quality and reliability. Companies seeking to buy this intermediate often look for established players in the market, including those in China.
  • Technical Documentation: Access to SDS and TDS is vital for safety protocols and experimental design. A responsive supplier will readily provide these documents.
  • Supply Chain Stability: For drug development projects, securing a consistent and scalable supply of intermediates is critical. Investigate the supplier's production capacity and logistical capabilities.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of high-quality trans-1,2-cyclohexanedicarboxylic acid. We empower pharmaceutical companies and research institutions to procure essential chemical building blocks for developing innovative treatments like those for osteoarthritis. Reach out to us for a quote and to discuss your procurement needs for this vital chemical intermediate.