In the highly regulated pharmaceutical industry, the purity of raw materials and intermediates is non-negotiable. For compounds like 2-Chloro-1,4-Naphthoquinone (CAS 1010-60-2), which serves as a critical intermediate in the synthesis of vital drugs, adherence to stringent purity standards is paramount. Sourcing this compound from reliable manufacturers, especially those based in China, requires a keen understanding of the essential specifications that guarantee product integrity.

The Criticality of Purity in Pharmaceutical Intermediates

2-Chloro-1,4-Naphthoquinone, a yellow crystalline powder, is a key component in the production of Atovaquone, a cornerstone medication for treating malaria and Pneumocystis pneumonia. The synthesis process for such drugs is sensitive to the quality of its building blocks. Impurities in 2-Chloro-1,4-Naphthoquinone could lead to:

  • Reduced yield in subsequent synthesis steps.
  • Formation of unwanted by-products that are difficult to remove.
  • Compromised efficacy or safety of the final Active Pharmaceutical Ingredient (API).
  • Regulatory compliance issues during drug approval processes.

Therefore, when a pharmaceutical company looks to buy 2-Chloro-1,4-Naphthoquinone, they prioritize suppliers who can guarantee high purity levels. A typical specification from a reputable manufacturer, such as NINGBO INNO PHARMCHEM CO.,LTD., would include a minimum purity of 98%, along with limits for specific impurities and loss on drying.

Key Specifications to Verify When Buying

When evaluating potential suppliers for 2-Chloro-1,4-Naphthoquinone, particularly those operating as a manufacturer in China, procurement professionals should pay close attention to the following:

  • Assay/Purity: Look for a minimum assay of 98% or higher.
  • Loss on Drying (LOD): This indicates the moisture content. For sensitive compounds, a low LOD (e.g., ≤0.5%) is desirable.
  • Impurity Profile: Check for specified limits on known process-related impurities, such as naphthoquinone dichloride, and total impurities.
  • Appearance: The consistent yellow crystalline powder form is an important visual indicator of quality.
  • CAS Number: Confirming CAS 1010-60-2 is essential for accurate identification.

Partnering with a Trusted China Supplier

NINGBO INNO PHARMCHEM CO.,LTD. is committed to delivering 2-Chloro-1,4-Naphthoquinone that meets these stringent pharmaceutical requirements. As a seasoned manufacturer and supplier, we understand the critical importance of purity and reliability. Our transparent approach ensures that clients have all the necessary information to make informed purchasing decisions, securing a consistent and high-quality supply chain for their Atovaquone intermediate needs. By prioritizing quality assurance and robust manufacturing practices, we aim to be the preferred partner for your pharmaceutical intermediate sourcing.