For research and development scientists, the quality and specifications of chemical reagents are the bedrock of experimental success. D-3-Chloro-D-phenylalanine (CAS 80126-52-9), a vital unnatural amino acid, is no exception. Understanding its key specifications ensures that researchers can confidently incorporate it into peptide synthesis, drug design, and biochemical studies. This guide outlines the critical parameters to consider when purchasing this compound, focusing on what R&D professionals should look for from their suppliers.

The most critical specification for D-3-Chloro-D-phenylalanine is its purity. Typically, researchers will require a high chemical purity, often specified as ≥97% or ≥98% by High-Performance Liquid Chromatography (HPLC). This high purity minimizes the risk of side reactions and ensures that the synthesized peptides or drug molecules possess the intended structure and properties. Equally important is the enantiomeric purity, as the D-configuration is crucial for many stereospecific biological interactions. Suppliers should provide data on optical rotation (e.g., [α]D) to confirm the correct stereochemistry.

Other essential specifications include the physical appearance, which is typically a white to off-white powder, and the molecular weight (approximately 199.63 g/mol). Information regarding solubility in common organic solvents (like chloroform, DCM, ethyl acetate) is also beneficial for experimental planning. Researchers should also pay attention to the storage conditions recommended by the manufacturer, usually requiring refrigeration (0-8°C) to maintain stability and prevent degradation.

When you buy D-3-Chloro-D-phenylalanine, always request a comprehensive Certificate of Analysis (CoA). This document should detail the lot-specific results for purity (HPLC), identity (e.g., NMR, Mass Spectrometry), optical rotation, and physical appearance. A reliable manufacturer or supplier, especially those operating in China, will readily provide these details. By meticulously checking these specifications, R&D scientists can ensure they are using a high-quality intermediate that will contribute to the success of their demanding research projects.