For businesses operating in the chemical and pharmaceutical sectors, the quality of raw materials is not just a preference; it's a fundamental requirement that impacts product efficacy, safety, and regulatory compliance. 4-Hydroxyphenylacetic Acid (4-HPAA), a critical intermediate, exemplifies this principle. Ensuring you source high-purity 4-HPAA is paramount for successful synthesis and formulation.

Understanding the Specifications of 4-Hydroxyphenylacetic Acid

4-Hydroxyphenylacetic Acid (CAS: 156-38-7) is typically supplied as a white powder. The key specification that dictates its suitability for sensitive applications, particularly pharmaceutical synthesis, is its purity. Reputable manufacturers will offer 4-HPAA with a purity of ≥99%. Beyond assay purity, other important parameters include moisture content (Loss on Drying), residue on ignition, and melting point (typically 148-151°C). For R&D scientists and procurement managers, these specifications are critical benchmarks when evaluating potential suppliers.

The Importance of High Purity in Synthesis

In complex organic synthesis, even minor impurities can have significant downstream effects. For intermediates like 4-Hydroxyphenylacetic Acid used in the production of APIs such as Galantamine Hydrobromide or Olopatadine Hydrochloride, impurities can lead to:

  • Reduced reaction yields.
  • Formation of unwanted by-products, complicating purification.
  • Compromised efficacy or safety of the final drug product.
  • Challenges in meeting stringent regulatory requirements.

Therefore, a commitment to purchasing ≥99% pure 4-HPAA is a strategic investment in the quality of your end product.

Finding Reliable Suppliers and Manufacturers

When looking to buy 4-Hydroxyphenylacetic Acid, diligence in supplier selection is key. Prioritize manufacturers who provide comprehensive Certificates of Analysis (COA) detailing purity and other relevant specifications. Companies that openly share their quality control processes and can demonstrate a consistent track record are ideal partners. Many leading chemical manufacturers based in China, including NINGBO INNO PHARMCHEM CO.,LTD., specialize in producing high-purity pharmaceutical intermediates and are well-equipped to meet global demand.

Making an Informed Purchase Decision

For procurement professionals, comparing offers based not just on price but also on quality assurance is crucial. Requesting samples for internal validation is a standard practice to confirm that the supplier's product meets your exact needs. Establishing a relationship with a dependable supplier ensures a stable supply chain, allowing your R&D and production teams to focus on innovation and manufacturing without concern for raw material quality.

By adhering to these quality-focused procurement principles, you can confidently source the high-purity 4-Hydroxyphenylacetic Acid necessary to drive your chemical and pharmaceutical projects forward.