Erlotinib Synthesis: The Critical Role of High-Purity 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone
The synthesis of complex pharmaceutical molecules is a multi-step process, each step requiring precise control over chemical reactions and the purity of starting materials. For Erlotinib, a vital targeted therapy in oncology, the intermediate 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone (CAS: 179688-29-0) is absolutely crucial. NINGBO INNO PHARMCHEM CO.,LTD. plays a significant role in this supply chain by manufacturing this compound to the highest standards, ensuring that pharmaceutical companies have access to a reliable source for their production needs.
Erlotinib, known for its effectiveness against certain types of lung and pancreatic cancer, functions by inhibiting the epidermal growth factor receptor (EGFR). The chemical structure of Erlotinib is built upon a quinazoline core, and 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone provides precisely this core structure, along with the necessary side chains, for subsequent reactions. The purity of this intermediate, consistently maintained at ≥99.0% by NINGBO INNO PHARMCHEM CO.,LTD., is paramount. Even minor impurities can affect the yield and purity of the final Erlotinib hydrochloride, potentially leading to regulatory hurdles or compromised therapeutic effectiveness. Therefore, when seeking to buy this intermediate, partnering with a manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures that your synthesis begins with a foundation of quality.
The synthesis pathways commonly involve coupling 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone with specific aniline derivatives. The reliability of the intermediate's physical properties, such as its white solid form and consistent melting point, aids in the predictability and scalability of these reactions. As a manufacturer based in China, NINGBO INNO PHARMCHEM CO.,LTD. leverages its expertise to produce this intermediate efficiently and cost-effectively, without compromising on the stringent purity requirements dictated by the pharmaceutical industry. This focus on both quality and value makes us a preferred supplier.
For any company involved in the production of Erlotinib, securing a consistent supply of high-quality 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone is a critical strategic decision. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting the pharmaceutical sector by providing this essential building block, thereby contributing to the availability of effective cancer treatments worldwide.
Perspectives & Insights
Molecule Vision 7
“The synthesis pathways commonly involve coupling 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone with specific aniline derivatives.”
Alpha Origin 24
“The reliability of the intermediate's physical properties, such as its white solid form and consistent melting point, aids in the predictability and scalability of these reactions.”
Future Analyst X
“leverages its expertise to produce this intermediate efficiently and cost-effectively, without compromising on the stringent purity requirements dictated by the pharmaceutical industry.”