In the intricate world of pharmaceutical manufacturing, the quality and reliability of every component are paramount. For the production of Vildagliptin, a leading medication for managing type 2 diabetes, the intermediate (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile (CAS 207557-35-5) is a critical starting material. Its precise chemical structure and stereochemistry are foundational to the drug's therapeutic efficacy.

Why (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile is Crucial

(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile is a chiral molecule, meaning it exists in two non-superimposable mirror-image forms (enantiomers). For Vildagliptin, only the (2S) isomer exhibits the desired pharmacological activity as a DPP-4 inhibitor. Therefore, pharmaceutical synthesis processes demand this intermediate with a high degree of enantiomeric purity. The chloroacetyl group also provides a reactive site for the subsequent chemical modifications required to form Vildagliptin. Manufacturers and R&D scientists rely on suppliers who can consistently deliver this intermediate with verifiable quality, ensuring the final API meets strict regulatory standards.

Procurement Insights for Pharmaceutical Professionals

When seeking to purchase (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile, pharmaceutical procurement managers and R&D teams prioritize several key factors:

  • Purity and Enantiomeric Excess: A high chemical purity (often >98%) and a high enantiomeric excess (e.e.) for the (2S) isomer are essential. Suppliers must provide comprehensive Certificates of Analysis (CoA).
  • Reliable Supply and Capacity: Ensuring a stable and scalable supply chain from the manufacturer is crucial to avoid production interruptions.
  • Competitive Pricing: Obtaining a favorable price for bulk orders is a significant consideration for cost management in API production.
  • Technical Support and Documentation: Access to Safety Data Sheets (SDS) and detailed product information aids in safe handling and efficient process integration.

Many global pharmaceutical companies choose to partner with specialized chemical companies, particularly those in China, to source critical intermediates like (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile. These suppliers often offer advanced synthesis capabilities and competitive pricing, making them valuable partners in the pharmaceutical supply chain.

NINGBO INNO PHARMCHEM CO.,LTD. is a committed supplier of high-quality pharmaceutical intermediates. We understand the stringent requirements for Vildagliptin synthesis and ensure our (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile meets the highest standards. We invite all professionals in pharmaceutical research and development, as well as procurement specialists, to contact us for inquiries, to request a product quote, and to discuss your needs for this vital chemical intermediate.