The pharmaceutical industry is constantly evolving, with targeted therapies becoming increasingly important in treating complex diseases like cancer. Crizotinib, a potent ALK and ROS1 inhibitor, represents a significant advancement in the treatment of certain types of non-small cell lung cancer (NSCLC). The synthesis of such a complex molecule requires precise chemical building blocks, among which (R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine (CAS: 877399-00-3) plays a pivotal role.

For professionals involved in API manufacturing and pharmaceutical R&D, understanding the function and sourcing of this intermediate is crucial. If you are looking to buy this compound, it's essential to partner with a reliable manufacturer and supplier that guarantees its quality and availability.

What is (R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine?

This compound is a chiral intermediate, meaning it possesses a specific three-dimensional structure essential for its intended function in the synthesis pathway of Crizotinib. Its chemical structure includes a brominated pyridine ring and a dichlorofluorophenyl ethoxy side chain, with a specific 'R' configuration at a chiral center. This precise arrangement is what allows it to participate effectively in the subsequent reaction steps to form the final Crizotinib molecule.

Key Properties and Specifications

As a leading provider of pharmaceutical intermediates, we ensure that our (R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine meets high standards. Key specifications typically include:

  • Appearance: Light yellow solid.
  • Purity: Typically ≥98.0% (HPLC).
  • Chiral Purity: High enantiomeric excess (e.e.) is critical.
  • Storage: Recommended to be stored in a cool, ventilated place.

These specifications are vital for ensuring the successful synthesis of Crizotinib, impacting its efficacy and safety as an anti-cancer drug.

The Importance of Sourcing from a Reliable Manufacturer

The complexity of synthesizing chiral intermediates means that quality control is paramount. When you choose to purchase this intermediate, partnering with a reputable supplier is essential. A trusted manufacturer will ensure:

  • Consistent Purity: Batch-to-batch consistency is crucial for scalable pharmaceutical production.
  • Accurate Chirality: The correct enantiomer must be provided to ensure therapeutic efficacy.
  • Reliable Supply: Secure and timely delivery to meet production schedules.
  • Competitive Pricing: Offering value for money, especially for bulk orders.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being that reliable partner. We leverage our expertise as a Chinese manufacturer to supply high-quality (R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine. We understand the critical nature of these intermediates for life-saving medications.

If your company requires this essential compound for Crizotinib production or other research applications, we invite you to inquire with us. Explore how our commitment to quality and service can support your manufacturing objectives.