For chemists, formulators, and procurement managers in the pharmaceutical and fine chemical industries, understanding the precise specifications of a chemical compound is fundamental. Ethyl 3,4-bis(2-methoxyethoxy)benzoate, identified by its CAS number 183322-16-9, is a critical intermediate used in the synthesis of Erlotinib, a significant pharmaceutical agent. This article aims to provide a detailed overview of its chemical properties and offer guidance on selecting a reliable supplier for your sourcing needs.

Key Chemical Properties and Specifications

Ethyl 3,4-bis(2-methoxyethoxy)benzoate is characterized by its molecular formula C15H22O6 and a molecular weight of approximately 298.33 g/mol. Its EINECS number is 605-991-9. Physically, it is described as a white to almost white solid, with a melting point typically ranging between 55-58 °C. The boiling point is noted at approximately 401.7 ± 45.0 °C, and its density is around 1.102. For its primary application in pharmaceutical synthesis, particularly as an Erlotinib intermediate, high purity is essential. Reputable manufacturers often guarantee a purity level of ≥97%, with some offering ≥99% purity via Gas Chromatography (GC) analysis. These specifications are critical for ensuring the success of subsequent synthesis steps and the quality of the final API. When you decide to buy this chemical, always request a Certificate of Analysis (CoA) detailing these parameters.

The Importance of Purity and Application

The compound's role as an Erlotinib intermediate means that even minor impurities can have significant downstream effects. These could include reduced yields in synthesis, the formation of unwanted by-products, or even the presence of contaminants in the final drug substance. Therefore, sourcing from manufacturers who employ robust purification techniques and stringent quality control is paramount. The presence of the two methoxyethoxy groups and the ethyl ester on the benzoate core makes this molecule a specific and valuable precursor for constructing the complex structure of Erlotinib, a targeted therapy for certain cancers. If your R&D efforts or manufacturing processes require this specific intermediate, ensuring its quality is the first step to success.

Selecting a Reliable Manufacturer and Supplier

Choosing the right manufacturer and supplier for Ethyl 3,4-bis(2-methoxyethoxy)benzoate is a strategic decision. When looking to purchase this chemical, consider suppliers with a proven track record in producing pharmaceutical intermediates. Key indicators of reliability include:

  • Established Quality Systems: Look for ISO certifications or GMP compliance.
  • Comprehensive Documentation: Availability of CoA, MSDS, and potentially Route of Synthesis (ROS).
  • Production Capacity and Scalability: Can they meet your current and future volume requirements?
  • Competitive Pricing: Obtain quotes and compare offerings for bulk purchases.
  • Customer Service and Technical Support: A responsive supplier can resolve queries efficiently.

Many leading chemical suppliers operate from China, offering competitive pricing and a wide range of products. By focusing on these criteria, procurement managers and R&D scientists can effectively identify and secure a dependable source for this crucial pharmaceutical intermediate, ensuring the continuity and quality of their critical drug manufacturing operations.