Understanding Ethyl 5-Formyl-2,4-Dimethylpyrrole-3-Carboxylate: Properties and Applications
Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (CAS: 2199-59-9) is a compound of significant interest within the chemical and pharmaceutical industries, primarily due to its utility as a versatile intermediate. Understanding its physical and chemical properties is key to appreciating its role in complex synthesis pathways.
Physically, this compound is typically presented as an off-yellow powder. Its molecular formula is C10H13NO3, and it has a molecular weight of 195.215 g/mol. Key physical properties include a density of approximately 1.173 g/cm³, a high boiling point of 358.4ºC at 760 mmHg, and a flash point of 170.5ºC. These characteristics contribute to its stability and suitability for various reaction conditions encountered in pharmaceutical manufacturing.
Chemically, the presence of both an aldehyde (-CHO) group and an ester (-COOEt) group on the pyrrole ring makes it a highly reactive and adaptable building block. The pyrrole ring itself is a fundamental heterocyclic structure found in many biologically active molecules. The specific substitution pattern at positions 2, 3, 4, and 5 of the pyrrole ring in this compound dictates its reactivity and its suitability for particular synthetic routes.
One of the most prominent applications of Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate is its use as a crucial intermediate in the synthesis of Sunitinib Malate. Sunitinib Malate is a potent multi-targeted receptor tyrosine kinase (RTK) inhibitor used in the treatment of certain cancers, such as advanced renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumors (GIST). The reliable supply of this high-purity pyrrole derivative is critical for the efficient and cost-effective production of Sunitinib Malate.
As a manufacturer dedicated to providing top-tier pharmaceutical chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. ensures that Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate meets stringent purity specifications, typically ≥99.0%. This adherence to quality standards is vital for the pharmaceutical industry, where even minor impurities can have significant impacts on drug efficacy and safety. Our commitment to excellence in chemical synthesis makes us a preferred partner for companies involved in the development and manufacturing of advanced pharmaceuticals.
In summary, Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate is a compound with well-defined physical and chemical properties that make it an indispensable intermediate in the synthesis of important pharmaceuticals. Its role in creating life-saving drugs highlights the importance of reliable fine chemical manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. in supporting global health initiatives.
Physically, this compound is typically presented as an off-yellow powder. Its molecular formula is C10H13NO3, and it has a molecular weight of 195.215 g/mol. Key physical properties include a density of approximately 1.173 g/cm³, a high boiling point of 358.4ºC at 760 mmHg, and a flash point of 170.5ºC. These characteristics contribute to its stability and suitability for various reaction conditions encountered in pharmaceutical manufacturing.
Chemically, the presence of both an aldehyde (-CHO) group and an ester (-COOEt) group on the pyrrole ring makes it a highly reactive and adaptable building block. The pyrrole ring itself is a fundamental heterocyclic structure found in many biologically active molecules. The specific substitution pattern at positions 2, 3, 4, and 5 of the pyrrole ring in this compound dictates its reactivity and its suitability for particular synthetic routes.
One of the most prominent applications of Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate is its use as a crucial intermediate in the synthesis of Sunitinib Malate. Sunitinib Malate is a potent multi-targeted receptor tyrosine kinase (RTK) inhibitor used in the treatment of certain cancers, such as advanced renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumors (GIST). The reliable supply of this high-purity pyrrole derivative is critical for the efficient and cost-effective production of Sunitinib Malate.
As a manufacturer dedicated to providing top-tier pharmaceutical chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. ensures that Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate meets stringent purity specifications, typically ≥99.0%. This adherence to quality standards is vital for the pharmaceutical industry, where even minor impurities can have significant impacts on drug efficacy and safety. Our commitment to excellence in chemical synthesis makes us a preferred partner for companies involved in the development and manufacturing of advanced pharmaceuticals.
In summary, Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate is a compound with well-defined physical and chemical properties that make it an indispensable intermediate in the synthesis of important pharmaceuticals. Its role in creating life-saving drugs highlights the importance of reliable fine chemical manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. in supporting global health initiatives.
Perspectives & Insights
Silicon Analyst 88
“Its role in creating life-saving drugs highlights the importance of reliable fine chemical manufacturers like NINGBO INNO PHARMCHEM CO.”
Quantum Seeker Pro
“Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (CAS: 2199-59-9) is a compound of significant interest within the chemical and pharmaceutical industries, primarily due to its utility as a versatile intermediate.”
Bio Reader 7
“Understanding its physical and chemical properties is key to appreciating its role in complex synthesis pathways.”