Ethyl chloroacetate, known chemically as ethyl 2-chloroacetate or chloroacetic acid ethyl ester, is a cornerstone organic compound with significant utility across multiple industries, most notably pharmaceuticals. Its CAS number, 105-39-5, identifies a colorless, transparent liquid possessing unique chemical and physical properties that make it invaluable for synthesis and manufacturing. Understanding these attributes and the production landscape, especially from leading regions like China, is crucial for procurement managers and R&D scientists.

Key Chemical and Physical Properties

Ethyl chloroacetate (C4H7ClO2, Molecular Weight: 122.55) exhibits a density of 1.15 g/cm³ and a boiling point of 143°C at 15 mmHg. Its low melting point of -26°C and flash point of 150°F are important considerations for handling and storage. While insoluble in water, it readily dissolves in common organic solvents like ethanol and ether, facilitating its use in various organic reactions. The typical specification for high-quality ethyl chloroacetate includes a purity of ≥99%, with tight controls on by-products such as dichloroacetic acid methyl ester (≤0.5%), moisture (≤0.1%), and acidity (≤0.07%). These precise specifications are vital for its application as a pharmaceutical intermediate, especially when preparing to buy ethyl chloroacetate for sensitive processes.

Manufacturing Excellence in China: A Global Hub

China has emerged as a leading global supplier of ethyl chloroacetate, driven by its advanced chemical manufacturing infrastructure and expertise. Manufacturers in China have refined the esterification process of chloroacetic acid with ethanol, often employing sulfuric acid as a catalyst, to achieve high yields and exceptional purity. The commitment to quality control, including rigorous testing for all specified parameters, ensures that Chinese-produced ethyl chloroacetate meets international standards. For businesses seeking a reliable ethyl chloroacetate supplier, the scale and technological advancement found in China offer significant advantages. When you purchase ethyl chloroacetate, opting for a Chinese manufacturer can provide competitive pricing and consistent availability.

Primary Applications: Pharmaceuticals and Beyond

The most prominent application of ethyl chloroacetate is as a key intermediate in the synthesis of Cefazolin sodium (CAS: 27164-46-1), a critical antibiotic. Its role in forming five-membered heterocycles is central to the production of this vital pharmaceutical. Beyond its pharmaceutical significance, ethyl chloroacetate is also utilized in the production of agrochemicals, serving as a precursor for pesticides and herbicides. Its reactivity also lends itself to the fragrance industry, where it acts as a building block for creating complex aromatic compounds. This wide array of uses highlights the demand for high-quality chloroacetic acid ethyl ester.

Safety and Handling Considerations

As a reactive chemical, ethyl chloroacetate requires careful handling. Its flammable nature and potential for eye irritation necessitate appropriate safety measures, including proper ventilation and the use of personal protective equipment (PPE). Storage should be in cool, dry, well-closed containers, away from moisture, strong light, and heat sources. Reputable suppliers will provide comprehensive Safety Data Sheets (SDS) to guide safe usage and storage protocols. Understanding these precautions is essential for anyone looking to source and utilize this compound.

Choosing Your Ethyl Chloroacetate Partner

When selecting an ethyl chloroacetate manufacturer, consider their production capacity, quality assurance systems, and export experience. Partnering with a Chinese supplier like NINGBO INNO PHARMCHEM CO.,LTD. can offer a reliable and cost-effective solution for your ethyl chloroacetate needs. We are dedicated to providing high-purity intermediates that meet the demanding requirements of the global pharmaceutical and chemical industries. Contact us today to learn more about our product specifications, pricing, and how we can support your manufacturing objectives when you need to buy ethyl chloroacetate.