Cross-coupling reactions have revolutionized organic synthesis, enabling the efficient formation of carbon-carbon and carbon-heteroatom bonds. Among the versatile reagents facilitating these powerful transformations, 2-Bromothiophene (CAS: 1003-09-4) stands out due to its thiophene core and reactive bromine atom. NINGBO INNO PHARMCHEM CO.,LTD., a leading manufacturer and supplier, provides the high-purity 2-Bromothiophene essential for these advanced synthetic methodologies.

The Role of 2-Bromothiophene in Catalytic Cross-Coupling
The thiophene ring is a ubiquitous scaffold in pharmaceuticals, agrochemicals, and materials science. 2-Bromothiophene serves as an excellent starting material for introducing this moiety into larger, more complex molecules via metal-catalyzed cross-coupling reactions. The bromine atom, being a good leaving group, readily participates in reactions such as:

  • Suzuki-Miyaura Coupling: Reaction with organoboron compounds in the presence of a palladium catalyst to form new C-C bonds. This is widely used to attach aryl or vinyl groups to the thiophene ring.
  • Stille Coupling: Coupling with organotin compounds, also palladium-catalyzed, to create C-C bonds. This reaction is known for its functional group tolerance.
  • Sonogashira Coupling: A palladium- and copper-catalyzed reaction with terminal alkynes to form C-C bonds, creating alkynylthiophenes.
  • Heck Coupling: Reaction with alkenes under palladium catalysis to form vinylthiophenes.
  • Buchwald-Hartwig Amination: Palladium-catalyzed coupling with amines to form C-N bonds, introducing amino functionalities onto the thiophene ring.

Purity and Reactivity: What to Look For
The success of cross-coupling reactions hinges on the purity and reactivity of the starting materials. Impurities in 2-Bromothiophene can poison the catalyst, lead to side reactions, and significantly reduce yields. NINGBO INNO PHARMCHEM CO.,LTD. is committed to delivering 2-Bromothiophene with a minimum purity of ≥99%, ensuring optimal reactivity and predictable outcomes for your catalytic transformations. Researchers looking to reliably buy this intermediate rely on consistent quality.

Partnering with a Trusted Manufacturer
As a dedicated manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. offers not just high-quality 2-Bromothiophene but also the assurance of a stable supply chain. We understand the critical nature of these reactions in advancing scientific discovery and industrial processes. Our expertise in chemical synthesis and production, combined with competitive prices, makes us an ideal partner for your chemical needs. We are a reliable supplier in China, equipped to handle orders from laboratory scale to commercial production.

For chemists and researchers who depend on the efficiency and versatility of cross-coupling reactions, sourcing high-grade 2-Bromothiophene is essential. We invite you to contact NINGBO INNO PHARMCHEM CO.,LTD. to request a quote and discuss how our product can support your next synthetic breakthrough. When you need to purchase this vital reagent, choose the quality and dependability that defines our commitment to excellence.