In the realm of specialty chemicals, understanding the intricate details of a compound's chemistry and supply chain is vital for both researchers and procurement professionals. 3-Bromo-5-fluoroanisole (CAS 29578-39-0) is one such compound that warrants close examination due to its utility in advanced synthesis, particularly within the pharmaceutical and fine chemical industries. This article provides expert insights into its properties, synthesis, handling, and the importance of sourcing from reputable manufacturers.

Chemical Profile and Properties

3-Bromo-5-fluoroanisole, with the chemical formula C7H6BrFO, is a halogenated aromatic ether. Its molecular structure features a benzene ring substituted with a bromine atom at the 3-position, a fluorine atom at the 5-position, and a methoxy group (-OCH3) at the 1-position. This specific substitution pattern renders it highly valuable in organic synthesis. Typically appearing as a colorless to light yellow liquid, it has a boiling point around 94°C at 17 mmHg and a density of approximately 1.59 g/cm³. It is also noted as being light-sensitive, requiring appropriate storage conditions, generally between 2-8°C, to maintain its integrity.

Synthesis and Reactions

The synthesis of 3-Bromo-5-fluoroanisole often involves nucleophilic aromatic substitution reactions, such as the reaction of 1-bromo-3,5-difluorobenzene with sodium methoxide in a polar aprotic solvent like DMF. The resulting product can then be purified. The reactivity of 3-Bromo-5-fluoroanisole lies in its versatile functional groups. The bromine atom readily participates in metal-catalyzed cross-coupling reactions, enabling the formation of carbon-carbon bonds. The fluorine atom can influence the electronic properties and metabolic stability of molecules it is incorporated into, while the methoxy group can be manipulated or serve as a directing group.

Applications and Handling Considerations

3-Bromo-5-fluoroanisole serves as a crucial intermediate in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and advanced materials. Its structure makes it a key component in building libraries of potential drug candidates or in creating specialized functional molecules. When handling this chemical, standard laboratory safety precautions are essential. This includes wearing appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Ensure adequate ventilation and avoid inhalation or skin contact, as indicated by its hazard statements (e.g., H315 - Causes skin irritation, H319 - Causes serious eye irritation, H335 - May cause respiratory irritation).

Sourcing from a Trusted Manufacturer

For professionals seeking to buy 3-Bromo-5-fluoroanisole, partnering with a reliable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. is crucial. We ensure high purity standards, consistent product quality, and competitive pricing. Our expertise as a chemical supplier in China allows us to efficiently meet the demands of global clients. When you choose our company, you are assured of timely delivery, comprehensive technical support, and a commitment to client satisfaction. We understand the importance of a stable supply chain for your R&D and production needs, making us your ideal partner for specialty chemical procurement.