2,6-Difluoronitrobenzene, identified by its CAS number 19064-24-5, is a significant organic compound widely recognized for its utility as a versatile building block in chemical synthesis. Its molecular structure, featuring two fluorine atoms and a nitro group substituted on a benzene ring, imparts unique reactivity that is highly sought after in various industrial and research applications. Understanding its properties and synthesis is key for chemists and procurement managers seeking reliable sources of this intermediate.

The chemical and physical characteristics of 2,6-Difluoronitrobenzene are well-documented. It typically appears as a brown liquid with a boiling point of 91-92 °C at 11 mmHg. Its density is approximately 1.503 g/mL at 25 °C. While slightly soluble in water, it shows better solubility in organic solvents like chloroform and methanol. These properties make it amenable to various reaction conditions and purification techniques, crucial for achieving the high purity required by many end-users.

One of the primary applications of 2,6-Difluoronitrobenzene lies in its role as a precursor for secondary amine synthesis. These amines are essential intermediates in the creation of various nitric oxide (NO) donors. Nitric oxide donors are compounds that release nitric oxide, a vital signaling molecule in biological systems, making them valuable in pharmaceutical research and development for cardiovascular diseases and other therapeutic areas. The specific arrangement of fluorine and nitro groups on the benzene ring facilitates the targeted synthesis of these complex amine structures, highlighting its importance as a fine chemical intermediate.

The synthesis of 2,6-Difluoronitrobenzene often involves the oxidation of 2,6-difluoroaniline. A common method involves using sodium perborate tetrahydrate in glacial acetic acid. This process, when optimized, yields the desired product with good efficiency. For businesses looking to procure this chemical, identifying reputable manufacturers and suppliers, particularly those based in China, is paramount. These suppliers often provide detailed product specifications, Certificates of Analysis (CoA), and can offer competitive pricing, especially for bulk purchases. Exploring options from established manufacturers ensures a stable supply chain, critical for ongoing production needs.

When considering the purchase of 2,6-Difluoronitrobenzene, factors such as purity levels, packaging options, and reliable delivery are crucial. Many suppliers offer different purity grades, with 97% or 98% purity being common for industrial applications. Understanding the market for this chemical, including current price trends and availability from various manufacturers, will assist procurement specialists in making informed decisions. For those interested in buying, reaching out to leading manufacturers directly can provide access to technical support and customized solutions, ensuring you secure the best product and price for your specific requirements.

In summary, 2,6-Difluoronitrobenzene (CAS: 19064-24-5) is a compound of significant industrial interest due to its unique chemical properties and its indispensable role in synthesizing important precursors for nitric oxide donors and other fine chemicals. By understanding its applications and seeking out reliable manufacturers and suppliers, businesses can effectively integrate this essential organic building block into their production processes.