3-Amino-1-adamantanol, identified by its CAS number 702-82-9, is a compound of significant interest within the pharmaceutical and fine chemical industries. Its unique adamantane cage structure, combined with an amino and a hydroxyl group, makes it a versatile building block for complex organic synthesis, particularly in the development of active pharmaceutical ingredients (APIs). As a trusted supplier of pharmaceutical intermediates, we aim to provide a comprehensive understanding of this compound’s characteristics and its critical applications.

The chemical properties of 3-Amino-1-adamantanol are key to its utility. It typically presents as a white to yellow crystalline powder, with a melting point around 265°C (with decomposition). Its stability under normal temperatures and pressures is a considerable advantage for storage and handling. The compound's solubility in organic solvents, while being insoluble in water, dictates its use in specific reaction environments. These physical and chemical attributes ensure that it can be reliably incorporated into various synthesis pathways by pharmaceutical manufacturers.

The primary and most recognized application for 3-Amino-1-adamantanol is its role as a crucial intermediate in the synthesis of Vildagliptin. Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, widely prescribed for the management of type 2 diabetes. The synthesis route for Vildagliptin heavily relies on the specific functional groups and the rigid structure provided by 3-Amino-1-adamantanol. Therefore, securing a consistent supply of high-purity 3-Amino-1-adamantanol from a reliable manufacturer is essential for pharmaceutical companies producing this vital medication.

Beyond its primary use, the adamantane scaffold itself is of interest in medicinal chemistry due to its lipophilic nature and metabolic stability. This suggests potential for 3-Amino-1-adamantanol as a starting material or intermediate in the research and development of other novel pharmaceutical agents targeting various therapeutic areas. For R&D scientists, understanding the availability and sourcing of such specialized intermediates is crucial for advancing drug discovery programs.

As a premier supplier and manufacturer of pharmaceutical intermediates, we are dedicated to providing high-quality 3-Amino-1-adamantanol. We understand the importance of product integrity, timely delivery, and competitive pricing. If your organization is involved in the synthesis of Vildagliptin or exploring new adamantane-based pharmaceuticals, we encourage you to contact us to discuss your requirements for this critical intermediate. Our commitment is to support your innovation and production needs with excellence.