For chemists and researchers in the fields of pharmaceuticals and materials science, a thorough understanding of chemical intermediates is fundamental to innovation. 3-Thiophenecarboxaldehyde (CAS 498-62-4) is a prime example of such a compound, offering a unique combination of a thiophene ring and an aldehyde functional group that drives its diverse applications.

The chemical profile of 3-Thiophenecarboxaldehyde is defined by its molecular formula C5H4OS and a molecular weight of 112.15. Typically presented as a colorless to yellow liquid, its physical properties, such as a boiling point around 194-196 °C, indicate its suitability for various synthetic reactions. Its high purity, often exceeding 98% (GC), ensures predictable outcomes in sensitive chemical processes, making it a preferred choice for R&D professionals.

The primary application of 3-Thiophenecarboxaldehyde lies in its role as a pharmaceutical intermediate. It serves as a crucial building block in the synthesis of numerous active pharmaceutical ingredients (APIs). The thiophene moiety is frequently found in drug molecules, contributing to their biological activity and pharmacokinetic properties. Medicinal chemists leverage the aldehyde group for further functionalization, enabling the creation of complex molecular scaffolds essential for drug discovery.

Beyond pharmaceuticals, 3-Thiophenecarboxaldehyde is also employed as a reagent in polymer research. Its reactive aldehyde group can participate in polymerization reactions or be used to modify polymer architectures, leading to materials with specialized characteristics. Furthermore, it finds application in niche biological studies, particularly those examining the interactions of organoselenium and sulfur compounds.

For those looking to buy 3-Thiophenecarboxaldehyde, sourcing from reputable manufacturers and suppliers is essential. Companies often require rigorous quality control, with emphasis on purity and consistent supply. Obtaining quotes from established chemical suppliers, particularly those specializing in pharmaceutical intermediates and fine chemicals based in China, is a recommended procurement strategy. Proper storage, typically under refrigeration (2-8°C), is vital to maintain its chemical integrity.

In conclusion, 3-Thiophenecarboxaldehyde is a valuable and versatile chemical intermediate. Its well-defined chemical properties and broad applicability in pharmaceutical synthesis and polymer research make it a critical compound for research and development efforts. By understanding its characteristics and engaging with reliable suppliers, R&D professionals can effectively utilize this essential chemical in their groundbreaking work.