For chemists, material scientists, and procurement specialists, a deep understanding of a chemical's properties is fundamental to its effective utilization. 4-(Trifluoromethyl)benzonitrile, a key organic intermediate identified by CAS No. 455-18-5, presents a fascinating combination of physical and chemical characteristics that dictate its broad applicability. As a premier manufacturer and supplier, we provide this high-purity (≥99.0%) white crystalline compound, and are pleased to share insights into its properties and uses.

Physical and Chemical Properties: A Closer Look

4-(Trifluoromethyl)benzonitrile is characterized by its appearance as a white crystal. Its molecular formula is C8H4F3N, with a molecular weight of 171.11900. Key physical properties include a density of 1.278 g/mL at 25°C, a boiling point of 80-81°C at 20 mm Hg, and a melting point typically ranging from 39-41°C. The flash point is 161°F, and its refractive index is recorded at n20/D 1.4583. These properties are crucial for handling, storage, and designing reaction conditions. The presence of the trifluoromethyl group significantly influences the electron density of the benzene ring and the reactivity of the nitrile group, making it a versatile reagent.

Synthesizing Amidines and More

The primary application that drives demand for 4-(trifluoromethyl)benzonitrile is its role in the synthesis of amidines. This class of compounds is vital in medicinal chemistry, forming the structural basis of many therapeutic agents. The specific reactivity conferred by the trifluoromethyl and nitrile functionalities allows for efficient and selective formation of amidine structures. Researchers often look to buy this intermediate to construct complex molecules, including quinazoline derivatives, which are themselves significant in pharmaceutical development, particularly in oncology. Its reliable supply and consistent quality from a trusted manufacturer are key to success in these synthesis endeavors.

Applications in Cancer Research and Beyond

In the realm of scientific research, 4-(trifluoromethyl)benzonitrile is also employed in studies focusing on cancer cell proliferation. Understanding how cells grow and divide is fundamental to developing effective cancer treatments, and this compound serves as a valuable tool in such investigations. Its specific molecular interactions can provide insights into cellular pathways. For scientists needing to buy this compound for their research, ensuring high purity from a reputable supplier like us guarantees the reliability of their experimental results.

Securing Your Supply

As a dedicated supplier, we provide 4-(trifluoromethyl)benzonitrile in standard 25 kg drums, with options for custom packaging to meet diverse client needs. We understand the importance of a stable supply chain for both manufacturing and research. By choosing us as your chemical partner, you gain access to high-quality products, competitive pricing, and expert support, ensuring your procurement needs for this essential intermediate are met efficiently.