Fmoc-D-3-(3-Thienyl)-Alanine, identified by CAS number 220497-90-5, is a specialized unnatural amino acid that has garnered significant attention in chemical synthesis. Its structure, featuring the Fmoc protecting group and a thiophene ring attached to a D-alanine backbone, makes it a valuable building block for researchers and manufacturers in various scientific disciplines, most notably in peptide synthesis and drug development.

The synthesis of Fmoc-D-3-(3-Thienyl)-Alanine typically involves the N-protection of the corresponding D-3-(3-thienyl)alanine. This process is carried out under carefully controlled conditions to ensure the regioselectivity and high yield of the Fmoc derivative. The resulting compound, usually appearing as a white to off-white solid or powder, typically exhibits a purity of 97% or higher, a crucial specification for its use in sensitive applications like peptide synthesis. Manufacturers often employ rigorous quality control measures, including HPLC and NMR, to verify the purity and structural integrity of each batch.

The primary application of Fmoc-D-3-(3-Thienyl)-Alanine lies in its use as a monomer in Solid Phase Peptide Synthesis (SPPS). The Fmoc group allows for facile deprotection under basic conditions, which is orthogonal to the acid-labile side-chain protecting groups commonly used in SPPS. This orthogonality is critical for building complex peptide sequences with high fidelity. The thiophene side chain itself can introduce unique electronic and structural properties to the synthesized peptides, potentially influencing their biological activity, stability, or interaction with target molecules.

Beyond its role in peptide synthesis, the unique structure of Fmoc-D-3-(3-Thienyl)-Alanine also opens doors for applications in material science, particularly in the development of organic electronic materials. The thiophene moiety is a fundamental unit in many conductive polymers and organic semiconductors.

For entities looking to purchase Fmoc-D-3-(3-Thienyl)-Alanine, identifying reliable manufacturers and suppliers is paramount. Companies seeking to buy this material can benefit from the competitive landscape of global chemical suppliers, especially those based in China, known for their production capabilities. Ensuring a consistent supply of high-purity material is key to successful research and development, whether in academic labs or industrial settings. By partnering with knowledgeable suppliers, researchers can effectively leverage Fmoc-D-3-(3-Thienyl)-Alanine to advance their projects.