The field of medicinal chemistry continuously seeks novel compounds with enhanced therapeutic properties. Derivatives of 1-cinnamylpiperazine (CAS 18903-01-0) have garnered significant attention due to their diverse biological activities, particularly in areas like pain management and oncology. Understanding the synthesis routes and biological mechanisms is crucial for researchers looking to buy 1-(3-phenyl-2-propenyl)piperazine as a starting material.

Synthesis of 1-Cinnamylpiperazine Derivatives

The synthesis of 1-cinnamylpiperazine and its derivatives typically involves nucleophilic substitution reactions. A common method includes reacting piperazine with cinnamyl chloride. For more complex derivatives, such as those explored for anticancer applications or specific CNS targets, advanced coupling reactions, including palladium-catalyzed methods like Buchwald-Hartwig amination, are employed. Optimization of reaction parameters such as solvent, temperature, and reactant stoichiometry is vital for achieving high yields and purity, ensuring that the sourced CAS 18903-01-0 meets stringent quality demands.

Key Biological Activities and Applications

  • Opioid Receptor Agonism: Many 1-cinnamylpiperazine derivatives are potent agonists of the µ-opioid receptor (MOR). This property makes them candidates for developing new analgesics, offering an alternative to existing opioid medications. Research highlights specific analogs with significant MOR activation potential, making them valuable for pain relief studies.
  • Anticancer Potential: Hybrid molecules combining opioid tripeptide sequences with the 1-cinnamylpiperazine scaffold have shown promising cytotoxic effects against cancer cell lines, including pancreatic cancer. These compounds inhibit cell proliferation and induce apoptosis, indicating their potential as novel anticancer agents.
  • Neuropharmacological Interest: The piperazine moiety is known to interact with various central nervous system (CNS) targets, including dopamine and sigma receptors. Derivatives of 1-cinnamylpiperazine are being investigated for potential applications in treating neurological and psychiatric disorders.

Sourcing and Supply Chain Considerations

For researchers aiming to explore these therapeutic avenues, procuring high-quality 1-(3-phenyl-2-propenyl)piperazine is essential. When you intend to buy 1-cinnamylpiperazine, consider partnering with a reliable 1-(3-phenyl-2-propenyl)piperazine supplier China. Manufacturers specializing in pharmaceutical intermediates ensure the purity and consistency needed for your complex synthesis projects. A reputable CAS 18903-01-0 manufacturer will provide detailed specifications and support.

Conclusion

The versatility of 1-cinnamylpiperazine derivatives in modulating biological targets makes them valuable assets in modern pharmaceutical research. From developing advanced analgesics to exploring new anticancer therapies, this compound serves as a critical building block. By ensuring a reliable supply of high-quality 1-(3-phenyl-2-propenyl)piperazine, researchers can continue to push the boundaries of therapeutic innovation.

Keywords: 1-cinnamylpiperazine, CAS 18903-01-0, synthesis, biological activity, opioid receptor, anticancer, pharmaceutical intermediate, supplier.