Exploring the Chemical Properties and Reactivity of 3,5-Pyrazoledicarboxylic Acid
The utility of any chemical compound in synthesis is directly linked to its intrinsic chemical properties and reactivity. 3,5-Pyrazoledicarboxylic Acid (CAS 3112-31-0) is no exception. This article aims to provide a detailed exploration of its key chemical characteristics, including its physical state, stability, and typical reactions, to guide its optimal application in various chemical processes.
3,5-Pyrazoledicarboxylic Acid is typically described as a white crystalline powder. This solid form, combined with a relatively high melting point (around 292-295 °C with decomposition), indicates a stable compound under normal ambient conditions. Its molecular formula, C5H4N2O4, reveals a molecule with a heterocyclic pyrazole ring and two carboxylic acid functionalities. These carboxylic acid groups are acidic, with a predicted pKa of approximately 3.24, making the compound capable of forming salts with bases.
A significant characteristic of 3,5-Pyrazoledicarboxylic Acid is its ability to participate in hydrogen bonding. The presence of the N-H group on the pyrazole ring and the carboxylic acid groups allows for both intramolecular and intermolecular hydrogen bonding. This property influences its solubility, crystal packing, and reactivity. Reports suggest it has chemical stability that can be increased by the presence of other molecules, which is a valuable trait for chemical intermediates.
The reactivity of 3,5-Pyrazoledicarboxylic Acid stems primarily from its carboxylic acid groups and the pyrazole ring. The carboxylic acid groups can undergo typical reactions such as esterification with alcohols in the presence of an acid catalyst, and amidation with amines to form corresponding esters and amides. These transformations are fundamental for creating derivatives used in various applications, from polymers to pharmaceutical compounds.
The pyrazole ring itself can also be a site of reactivity. The nitrogen atoms in the ring possess lone pairs of electrons, making them potential sites for protonation or coordination with metal ions. Electrophilic aromatic substitution reactions can occur on the carbon atoms of the pyrazole ring, although the electron-withdrawing nature of the carboxylic acid groups might influence the regioselectivity and ease of these reactions. The compound's reaction mechanism can involve protonation at a nitrogen atom, leading to further transformations, as described in some literature.
As a supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. provides 3,5-Pyrazoledicarboxylic Acid that meets high purity standards, ensuring consistent chemical properties for your synthesis. Understanding these chemical properties and reactivity is key to efficiently using this compound as a valuable chemical building block. If you are looking to buy this product for your research or industrial needs, our company offers a reliable solution.
In summary, 3,5-Pyrazoledicarboxylic Acid is a stable, white crystalline powder with rich reactivity due to its pyrazole core and dicarboxylic acid functionalities. Its properties make it a versatile chemical building block for a wide range of synthetic applications, and a thorough understanding of its chemical behavior is crucial for maximizing its potential.
3,5-Pyrazoledicarboxylic Acid is typically described as a white crystalline powder. This solid form, combined with a relatively high melting point (around 292-295 °C with decomposition), indicates a stable compound under normal ambient conditions. Its molecular formula, C5H4N2O4, reveals a molecule with a heterocyclic pyrazole ring and two carboxylic acid functionalities. These carboxylic acid groups are acidic, with a predicted pKa of approximately 3.24, making the compound capable of forming salts with bases.
A significant characteristic of 3,5-Pyrazoledicarboxylic Acid is its ability to participate in hydrogen bonding. The presence of the N-H group on the pyrazole ring and the carboxylic acid groups allows for both intramolecular and intermolecular hydrogen bonding. This property influences its solubility, crystal packing, and reactivity. Reports suggest it has chemical stability that can be increased by the presence of other molecules, which is a valuable trait for chemical intermediates.
The reactivity of 3,5-Pyrazoledicarboxylic Acid stems primarily from its carboxylic acid groups and the pyrazole ring. The carboxylic acid groups can undergo typical reactions such as esterification with alcohols in the presence of an acid catalyst, and amidation with amines to form corresponding esters and amides. These transformations are fundamental for creating derivatives used in various applications, from polymers to pharmaceutical compounds.
The pyrazole ring itself can also be a site of reactivity. The nitrogen atoms in the ring possess lone pairs of electrons, making them potential sites for protonation or coordination with metal ions. Electrophilic aromatic substitution reactions can occur on the carbon atoms of the pyrazole ring, although the electron-withdrawing nature of the carboxylic acid groups might influence the regioselectivity and ease of these reactions. The compound's reaction mechanism can involve protonation at a nitrogen atom, leading to further transformations, as described in some literature.
As a supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. provides 3,5-Pyrazoledicarboxylic Acid that meets high purity standards, ensuring consistent chemical properties for your synthesis. Understanding these chemical properties and reactivity is key to efficiently using this compound as a valuable chemical building block. If you are looking to buy this product for your research or industrial needs, our company offers a reliable solution.
In summary, 3,5-Pyrazoledicarboxylic Acid is a stable, white crystalline powder with rich reactivity due to its pyrazole core and dicarboxylic acid functionalities. Its properties make it a versatile chemical building block for a wide range of synthetic applications, and a thorough understanding of its chemical behavior is crucial for maximizing its potential.
Perspectives & Insights
Nano Explorer 01
“Reports suggest it has chemical stability that can be increased by the presence of other molecules, which is a valuable trait for chemical intermediates.”
Data Catalyst One
“The reactivity of 3,5-Pyrazoledicarboxylic Acid stems primarily from its carboxylic acid groups and the pyrazole ring.”
Chem Thinker Labs
“The carboxylic acid groups can undergo typical reactions such as esterification with alcohols in the presence of an acid catalyst, and amidation with amines to form corresponding esters and amides.”