Understanding the fundamental chemical properties and synthesis pathways of key intermediates is vital for chemists and manufacturers engaged in organic synthesis. 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one (CAS 13185-18-7), often known by synonyms such as 8-Methoxy-1-Tetralone, is a compound with a distinct naphthalene structure that offers a rich platform for chemical transformations. This article explores its notable chemical characteristics and common synthesis methodologies, providing valuable insights for those looking to buy 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one.

The chemical profile of 8-Methoxy-1-Tetralone is defined by its molecular formula C11H12O2 and a molecular weight of approximately 176.21 g/mol. Key physical properties reported include a melting point typically in the range of 128-130°C, a boiling point around 325°C, and a density of 1.124 g/cm³. Its appearance is generally described as a white to off-white solid. These physical attributes are crucial for handling, storage, and process design.

Chemically, the molecule possesses a ketone group at the 1-position and a methoxy group at the 8-position of the dihydronaphthalene ring system. The ketone group is a reactive site susceptible to various nucleophilic additions, reductions, and enolate chemistry, enabling chain extensions and functional group interconversions. The methoxy group influences the electronic properties of the aromatic ring, potentially affecting electrophilic aromatic substitution reactions and overall solubility in organic solvents. This dual functionality makes it a versatile building block for constructing more complex organic molecules, particularly in the realm of pharmaceutical intermediates.

Regarding synthesis, one common route involves the reduction of a precursor, often a brominated or otherwise functionalized naphthalenone. For instance, a synthesis might start with 5-bromo-8-methoxy-3,4-dihydronaphthalen-1(2H)-one, which undergoes catalytic hydrogenation in methanol, utilizing a palladium on carbon catalyst under a nitrogen atmosphere. Following reaction completion, purification via column chromatography yields the desired product. Such detailed synthetic procedures are often available from reliable chemical suppliers when you seek to purchase organic synthesis chemicals online.

For manufacturers and researchers, sourcing this compound from a reputable manufacturer in China ensures access to the necessary quality and quantity. A good supplier will provide comprehensive technical documentation, including detailed synthesis information where applicable, and analytical data to confirm purity and identity. Understanding these chemical properties and synthesis routes empowers users to make informed decisions, whether they are optimizing existing processes or developing new synthetic strategies.

By focusing on the chemical nuances and reliable sourcing, professionals can effectively harness the potential of 8-Methoxy-3,4-dihydronaphthalen-1(2H)-one in their ongoing chemical endeavors.