Exploring the Chemical Properties of a Key Rucaparib Intermediate
The foundation of any successful drug synthesis lies in the precise understanding and utilization of its constituent intermediates. For Rucaparib, a significant advancement in cancer therapy, the intermediate 8-Fluoro-1,3,4,5-Tetrahydro-Azepino[5,4,3-cd]indol-6-one (CAS: 1408282-26-7) plays a pivotal role. This article aims to explore the detailed chemical properties of this essential Rucaparib intermediate and its significance in advanced organic synthesis.
Chemically, 8-Fluoro-1,3,4,5-Tetrahydro-Azepino[5,4,3-cd]indol-6-one is characterized by its molecular formula C11H9FN2O and a molecular weight of 204.20. It typically presents as a light yellow to off-white powder, indicating a stable crystalline form. The critical specification of HPLC purity, usually at or above 98.0%, ensures that this high purity pharmaceutical intermediate is suitable for complex chemical reactions where even trace impurities can have significant downstream effects. Furthermore, its low moisture content (≤1.0%) is a testament to careful manufacturing and packaging, preserving its reactivity and shelf-life.
The unique structural features, including the fluorine atom and the fused ring system of the azepinoindole core, make this compound a valuable component in organic synthesis. These features contribute to its reactivity and the specific stereochemical outcomes often desired in pharmaceutical production. As a critical building block for Rucaparib, understanding these properties allows chemists to optimize reaction conditions and maximize yields in the multi-step synthesis of this PARP inhibitor. Sourcing this intermediate from experienced China pharmaceutical intermediate suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that these precise chemical specifications are met consistently.
The development of effective cancer therapies like Rucaparib relies on the consistent availability of high-quality intermediates. Whether for API manufacturing or research in novel drug discovery, the chemical properties of 8-Fluoro-1,3,4,5-Tetrahydro-Azepino[5,4,3-cd]indol-6-one make it a compound of significant interest. NINGBO INNO PHARMCHEM CO.,LTD. provides this crucial component, supporting the advancement of medicinal chemistry and the production of essential pharmaceuticals.
Chemically, 8-Fluoro-1,3,4,5-Tetrahydro-Azepino[5,4,3-cd]indol-6-one is characterized by its molecular formula C11H9FN2O and a molecular weight of 204.20. It typically presents as a light yellow to off-white powder, indicating a stable crystalline form. The critical specification of HPLC purity, usually at or above 98.0%, ensures that this high purity pharmaceutical intermediate is suitable for complex chemical reactions where even trace impurities can have significant downstream effects. Furthermore, its low moisture content (≤1.0%) is a testament to careful manufacturing and packaging, preserving its reactivity and shelf-life.
The unique structural features, including the fluorine atom and the fused ring system of the azepinoindole core, make this compound a valuable component in organic synthesis. These features contribute to its reactivity and the specific stereochemical outcomes often desired in pharmaceutical production. As a critical building block for Rucaparib, understanding these properties allows chemists to optimize reaction conditions and maximize yields in the multi-step synthesis of this PARP inhibitor. Sourcing this intermediate from experienced China pharmaceutical intermediate suppliers like NINGBO INNO PHARMCHEM CO.,LTD. ensures that these precise chemical specifications are met consistently.
The development of effective cancer therapies like Rucaparib relies on the consistent availability of high-quality intermediates. Whether for API manufacturing or research in novel drug discovery, the chemical properties of 8-Fluoro-1,3,4,5-Tetrahydro-Azepino[5,4,3-cd]indol-6-one make it a compound of significant interest. NINGBO INNO PHARMCHEM CO.,LTD. provides this crucial component, supporting the advancement of medicinal chemistry and the production of essential pharmaceuticals.
Perspectives & Insights
Data Seeker X
“As a critical building block for Rucaparib, understanding these properties allows chemists to optimize reaction conditions and maximize yields in the multi-step synthesis of this PARP inhibitor.”
Chem Reader AI
“Sourcing this intermediate from experienced China pharmaceutical intermediate suppliers like NINGBO INNO PHARMCHEM CO.”
Agile Vision 2025
“The development of effective cancer therapies like Rucaparib relies on the consistent availability of high-quality intermediates.”